// Workers AI · dad joke modeWhat did AFTPH say to its friend? Nothing, it's a FTPH less.

Available protein structures:
PDB	IPR029205 PF15045 (ECOD; PDBsum)
AlphaFold	IPR029205; PF15045;

Clathrin-binding box of Aftiphilin
Clathrin-binding box of Aftiphilin
Identifiers
Symbol	Clathrin_bdg
Pfam	PF15045
InterPro	IPR029205
PDB
Available protein structures:
PDB	IPR029205 PF15045 (ECOD; PDBsum)
AlphaFold	IPR029205; PF15045;

AFTPH
Identifiers
Aliases	AFTPH, Nbla10388, aftiphilin
External IDs	MGI: 1923012; HomoloGene: 9764; GeneCards: AFTPH; OMA:AFTPH - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	64,593,005 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	20,691,589 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; male germ cell; ; sperm; ; buccal mucosa cell; ; cardia; ; epithelium of nasopharynx; ; cerebellar vermis; ; mucosa of ileum; ; beta cell; ; pylorus;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; spermatocyte; ; submandibular gland; ; lacrimal gland; ; dorsomedial hypothalamic nucleus; ; neural layer of retina; ; habenula; ; vestibular sensory epithelium; ; granulocyte; ; olfactory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	clathrin binding;
Cellular component	AP-1 adaptor complex; cytosol; Golgi apparatus; intracellular membrane-bounded organelle; nucleus; cytoplasm; trans-Golgi network membrane;
Biological process	protein transport; intracellular transport;
	Sources:Amigo / QuickGO
Orthologs
	54812
	216549
	ENSG00000119844
	ENSMUSG00000049659
	Q6ULP2
	Q80WT5
	NM_001002243; NM_017657; NM_203437
	NM_001252503; NM_001290545; NM_181411
NP_001002243; NP_060127; NP_982261; NP_001362898; NP_001362899;
	NP_001362900; NP_001362901; NP_001362902
	NP_001239432; NP_001277474; NP_852076
	Wikidata
View/Edit Human	View/Edit Mouse

Aftiphilin is a protein that in humans is encoded by the AFTPH gene.^[5]^[6]^[7] It forms a stable complex with p200 and synergin gamma.^[6]^[7] It contains a clathrin box with two known clathrin-binding sequence motifs, is involved in vesicle trafficking^[8] and is found in many eukaryotes.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000119844 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049659 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS (Feb 2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". J Biol Chem. 279 (9): 8018–28. doi:10.1074/jbc.M311873200. PMID 14665628.
1 2 Hirst J, Borner GH, Harbour M, Robinson MS (Apr 2005). "The aftiphilin/p200/gamma-synergin complex". Mol Biol Cell. 16 (5): 2554–65. doi:10.1091/mbc.E04-12-1077. PMC 1087257. PMID 15758025.
1 2 Burman JL, Wasiak S, Ritter B, de Heuvel E, McPherson PS (Apr 2005). "Aftiphilin is a component of the clathrin machinery in neurons". FEBS Lett. 579 (10): 2177–84. doi:10.1016/j.febslet.2005.03.008. PMID 15811338. S2CID 23970781.
↑ Lui-Roberts WW, Ferraro F, Nightingale TD, Cutler DF (December 2008). "Aftiphilin and gamma-synergin are required for secretagogue sensitivity of Weibel-Palade bodies in endothelial cells". Mol. Biol. Cell. 19 (12): 5072–81. doi:10.1091/mbc.E08-03-0301. PMC 2592662. PMID 18815278.

External links

Human AFTPH genome location and AFTPH gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000119844 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049659 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14665628-5] Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS (Feb 2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". J Biol Chem. 279 (9): 8018–28. doi:10.1074/jbc.M311873200. PMID 14665628.

[pmid15758025-6] 1 2 Hirst J, Borner GH, Harbour M, Robinson MS (Apr 2005). "The aftiphilin/p200/gamma-synergin complex". Mol Biol Cell. 16 (5): 2554–65. doi:10.1091/mbc.E04-12-1077. PMC 1087257. PMID 15758025.

[pmid15811338-7] 1 2 Burman JL, Wasiak S, Ritter B, de Heuvel E, McPherson PS (Apr 2005). "Aftiphilin is a component of the clathrin machinery in neurons". FEBS Lett. 579 (10): 2177–84. doi:10.1016/j.febslet.2005.03.008. PMID 15811338. S2CID 23970781.

[pmid18815278-8] Lui-Roberts WW, Ferraro F, Nightingale TD, Cutler DF (December 2008). "Aftiphilin and gamma-synergin are required for secretagogue sensitivity of Weibel-Palade bodies in endothelial cells". Mol. Biol. Cell. 19 (12): 5072–81. doi:10.1091/mbc.E08-03-0301. PMC 2592662. PMID 18815278.

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// Workers AI · dad joke modeWhat did AFTPH say to its friend? Nothing, it's a FTPH less.

References

External links

Further reading