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// Workers AI · dad joke modeIs AC927 a plane? Plane-ly obvious.

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From Wikipedia, the free encyclopedia
AC927
Clinical data
Other names1-Phenethylpiperidine; pip-PEA; Phenylethylpiperidine
Identifiers
  • 1-(2-phenylethyl)piperidine or N-phenethyl-piperidine
CAS Number
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.005.785 Edit this at Wikidata
Chemical and physical data
FormulaC13H19N
Molar mass189.302 g·mol−1

AC927 or 1-(2-phenylethyl)piperidine is a selective sigma receptor antagonist, with reported binding affinity of Ki = 30 ± 2 nM for the sigma-1 receptor and Ki = 138 ± 18 nM for the sigma-2 receptor, and negligible binding affinity for other major central nervous system receptors, transporters, and ion channels.[1]

AC927 is reported to attenuate the locomotor stimulation induced by methamphetamine in mice.[1]

References

[edit]
  1. 1 2 Matsumoto RR, Shaikh J, Wilson LL, Vedam S, Coop A (2008). "Attenuation of methamphetamine-induced effects through the antagonism of sigma (σ) receptors: Evidence from in vivo and in vitro studies". Eur. Neuropsychopharmacol. 18 (12): 871–81. doi:10.1016/j.euroneuro.2008.07.006. PMC 2688716. PMID 18755577.
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