// Workers AI · dad joke modeWhy ABI3 go to therapy? It had a gene-uine issue.

ABI3
Identifiers
Aliases	ABI3, NESH, SSH3BP3, ABI family member 3
External IDs	OMIM: 606363; MGI: 1913860; HomoloGene: 9505; GeneCards: ABI3; OMA:ABI3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.32 Start 49,210,411 bp End 49,223,225 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 D Start 95,720,900 bp End 95,733,302 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte spleen monocyte blood testicle appendix parotid gland apex of heart lymph node upper lobe of left lung Top expressed in thymus mesenteric lymph nodes interventricular septum granulocyte spleen tail of embryo blood gastrula right lung lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding SH3 domain binding Cellular component cytoplasm intracellular anatomical structure membrane lamellipodium Biological process peptidyl-tyrosine phosphorylation regulation of cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51225 66610 Ensembl ENSG00000108798 ENSMUSG00000018381 UniProt Q9P2A4 Q8BYZ1 RefSeq (mRNA) NM_001135186 NM_016428 NM_001163464 NM_025659 RefSeq (protein) NP_001128658 NP_057512 NP_001156936 NP_079935 Location (UCSC) Chr 17: 49.21 – 49.22 Mb Chr 11: 95.72 – 95.73 Mb PubMed search
Wikidata
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ABI gene family member 3 (ABI3) also known as new molecule including SH3 (Nesh) is a protein that in humans is encoded by the ABI3 gene.

Function

This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinases.

See also

• ABI1
• ABI2
• ABI3BP

External links

• Human ABI3 genome location and ABI3 gene details page in the UCSC Genome Browser.

Further reading

• Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S (2002). "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review)". Int. J. Mol. Med. 9 (6): 591–5. doi:10.3892/ijmm.9.6.591. PMID 12011975.
• Miyazaki K, Matsuda S, Ichigotani Y, et al. (2000). "Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein". Biochim. Biophys. Acta. 1493 (1–2): 237–41. doi:10.1016/s0167-4781(00)00158-5. PMID 10978530.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Matsuda S, Iriyama C, Yokozaki S, et al. (2001). "Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3". J. Hum. Genet. 46 (8): 483–6. doi:10.1007/s100380170049. PMID 11501947.
• Ichigotani Y, Yokozaki S, Fukuda Y, et al. (2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells". Cancer Res. 62 (8): 2215–9. PMID 11956071.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Hirao N, Sato S, Gotoh T, et al. (2007). "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation". FEBS Lett. 580 (27): 6464–70. doi:10.1016/j.febslet.2006.10.065. PMID 17101133. S2CID 20005197.