// Workers AI · dad joke modeWhat did ABI2 say to ABI1? "You're a byte behind.

ABI2
Identifiers
Aliases	ABI2, ABI-2, ABI2B, AIP-1, AblBP3, SSH3BP2, argBP1, argBPIA, argBPIB, abl-interactor 2, abl interactor 2, AIP1
External IDs	OMIM: 606442; MGI: 106913; GeneCards: ABI2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ED0, 3P8C, 4N78
Gene location (Human) Chr. Chromosome 2 (human) Band 2q33.2 Start 203,328,239 bp End 203,447,728 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 C2 Start 60,448,778 bp End 60,520,317 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 entorhinal cortex middle temporal gyrus postcentral gyrus external globus pallidus internal globus pallidus superior frontal gyrus superior vestibular nucleus ventral tegmental area lateral nuclear group of thalamus Top expressed in lateral septal nucleus olfactory tubercle anterior amygdaloid area primary motor cortex ventromedial nucleus piriform cortex Region I of hippocampus proper cingulate gyrus subiculum nucleus accumbens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding SH3 domain binding kinase binding protein binding cytoskeletal anchor activity proline-rich region binding ubiquitin protein ligase binding protein-containing complex binding protein tyrosine kinase activator activity Cellular component cytoplasm cytosol cell projection SCAR complex cytoskeleton lamellipodium filopodium filopodium tip dendrite nucleus adherens junction cell junction dendritic spine Biological process positive regulation of Arp2/3 complex-mediated actin nucleation cytoskeleton organization peptidyl-tyrosine phosphorylation Rac protein signal transduction viral process cell migration actin polymerization or depolymerization learning or memory dendrite development camera-type eye development nervous system development regulation of dendritic spine morphogenesis lens fiber cell morphogenesis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 10152 329165 Ensembl ENSG00000138443 ENSMUSG00000026782 UniProt Q9NYB9 P62484 RefSeq (mRNA) NM_001282925 NM_001282926 NM_001282927 NM_001282932 NM_005759 NM_001198570 NM_001198571 NM_198127 RefSeq (protein) NP_001269854 NP_001269855 NP_001269856 NP_001269861 NP_005750 NP_001362591 NP_001362592 NP_001362593 NP_001362594 NP_001362595 NP_001362596 NP_001362597 NP_001362598 NP_001362599 NP_001362600 NP_001362601 NP_001362602 NP_001362603 NP_001362604 NP_001362605 NP_001362606 NP_001362607 NP_001362608 NP_001362609 NP_001362610 NP_001362611 NP_001362612 NP_001362613 NP_001362614 NP_001362615 NP_001362616 NP_001362617 NP_001362618 NP_001362619 NP_001362620 NP_001362621 NP_001362622 NP_001362624 NP_001362625 NP_001362627 NP_001362628 NP_001362631 NP_001362633 NP_001362635 NP_001362636 NP_001362637 NP_001362638 NP_001362639 NP_001362640 NP_001362641 NP_001362643 NP_001362646 NP_001362648 NP_001362650 NP_001362651 NP_001362652 NP_001362653 NP_001362654 NP_001362655 NP_001362656 NP_001362657 NP_001362658 NP_001362659 NP_001362660 NP_001362661 NP_001362662 NP_001362663 NP_001362664 NP_001362665 NP_001362666 NP_001362667 NP_001362668 NP_001362669 NP_001362670 NP_001362671 NP_001362672 NP_001362673 NP_001362674 NP_001362675 NP_001362676 NP_001362677 NP_001362678 NP_001362679 NP_001362680 NP_001362681 NP_001362682 NP_001362683 NP_001362684 NP_001185499 NP_001185500 NP_937760 NP_001391634 NP_001391635 NP_001391636 NP_001391637 NP_001391638 NP_001391639 NP_001391640 NP_001391641 NP_001391642 NP_001391643 NP_001391644 NP_001391645 NP_001391646 NP_001391647 NP_001391648 NP_001391649 NP_001391650 Location (UCSC) Chr 2: 203.33 – 203.45 Mb Chr 1: 60.45 – 60.52 Mb PubMed search
Wikidata
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Abl interactor 2 also known as Abelson interactor 2 (Abi-2) is a protein that in humans is encoded by the ABI2 gene.

Interactions

ABI2 has been shown to interact with ABL1, ADAM19, and TRIM32.

Further reading

• Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S (2002). "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review)". International Journal of Molecular Medicine. 9 (6): 591–595. doi:10.3892/ijmm.9.6.591. PMID 12011975.
• Wang B, Mysliwiec T, Krainc D, Jensen RA, Sonoda G, Testa JR, et al. (May 1996). "Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene". Oncogene. 12 (9): 1921–1929. PMID 8649853.
• Juang JL, Hoffmann FM (1999). "Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity". Oncogene. 18 (37): 5138–5147. doi:10.1038/sj.onc.1202911. PMID 10498863.
• Chen B, Borinstein SC, Gillis J, Sykes VW, Bogler O (June 2000). "The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes". The Journal of Biological Chemistry. 275 (25): 19275–19281. doi:10.1074/jbc.M908994199. PMID 10858458.
• Courtney KD, Grove M, Vandongen H, Vandongen A, LaMantia AS, Pendergast AM (September 2000). "Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system". Molecular and Cellular Neurosciences. 16 (3): 244–257. doi:10.1006/mcne.2000.0865. PMID 10995551. S2CID 7370589.
• Stradal T, Courtney KD, Rottner K, Hahne P, Small JV, Pendergast AM (June 2001). "The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia". Current Biology. 11 (11): 891–895. Bibcode:2001CBio...11..891S. doi:10.1016/S0960-9822(01)00239-1. PMID 11516653. S2CID 1861695.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–716. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Eastman SW, Martin-Serrano J, Chung W, Zang T, Bieniasz PD (January 2005). "Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding". The Journal of Biological Chemistry. 280 (1): 628–636. doi:10.1074/jbc.M410384200. PMID 15509564.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Luo X, Levens E, Williams RS, Chegini N (2006). "The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta". Human Reproduction. 21 (6). Oxford, England: 1380–1386. doi:10.1093/humrep/del011. PMID 16488906.
• Hirao N, Sato S, Gotoh T, Maruoka M, Suzuki J, Matsuda S, et al. (November 2006). "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation". FEBS Letters. 580 (27): 6464–6470. doi:10.1016/j.febslet.2006.10.065. PMID 17101133. S2CID 20005197.
• Li Y, Clough N, Sun X, Yu W, Abbott BL, Hogan CJ, et al. (April 2007). "Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway". Journal of Cell Science. 120 (Pt 8): 1436–1446. doi:10.1242/jcs.03430. PMC 1950936. PMID 17389688.

External links

• ABI2 human gene location in the UCSC Genome Browser.
• ABI2 human gene details in the UCSC Genome Browser.