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This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.[7] Loss of function is implicated in hereditary cholestasis.
↑Tammur J, Prades C, Arnould I, Rzhetsky A, Hutchinson A, Adachi M, etal. (August 2001). "Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12". Gene. 273 (1): 89–96. doi:10.1016/S0378-1119(01)00572-8. PMID11483364.
Haimeur A, Conseil G, Deeley RG, Cole SP (2004). "The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation". Current Drug Metabolism. 5 (1): 21–53. doi:10.2174/1389200043489199. PMID14965249.
Yabuuchi H, Shimizu H, Takayanagi S, Ishikawa T (2001). "Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12". Biochemical and Biophysical Research Communications. 288 (4): 933–939. doi:10.1006/bbrc.2001.5865. PMID11688999.
