ABCA9
| ABCA9 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | ABCA9, EST640918, ATP binding cassette subfamily A member 9 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 612507; MGI: 2386796; GeneCards: ABCA9 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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ATP-binding cassette sub-family A member 9 is a protein that in humans is encoded by the ABCA9 gene.[5]
Function
[edit]This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two transmembrane domains and two nucleotide binding folds. ABC proteins transport various molecules across extra- and intracellular membranes. This gene is a member of the ABCA subfamily and is clustered with four other ABCA subfamily members on chromosome 17q24. Transcriptional expression of this gene is induced during monocyte differentiation into macrophages and is suppressed by cholesterol import.[5]
References
[edit]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000154258 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041797 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- 1 2 "Entrez Gene: ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9".
Further reading
[edit]- Dean M, Rzhetsky A, Allikmets R (2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Research. 11 (7): 1156–1166. doi:10.1101/gr.184901. PMID 11435397. S2CID 9528197.
- Piehler A, Kaminski WE, Wenzel JJ, Langmann T, Schmitz G (July 2002). "Molecular structure of a novel cholesterol-responsive A subclass ABC transporter, ABCA9". Biochemical and Biophysical Research Communications. 295 (2): 408–416. doi:10.1016/S0006-291X(02)00659-9. PMID 12150964.
- Allikmets R, Gerrard B, Hutchinson A, Dean M (1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Human Molecular Genetics. 5 (10): 1649–1655. doi:10.1093/hmg/5.10.1649. PMID 8894702.
- Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, et al. (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–828. doi:10.1101/gr.6.9.807. PMID 8889549.
External links
[edit]- ABCA9 human gene location in the UCSC Genome Browser.
- ABCA9 human gene details in the UCSC Genome Browser.
 | This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by adding missing information. |