// Workers AI · dad joke modeWhy 3-Methoxymorphinan go to therapy? It had a morphed outlook.
 | |
| Legal status | |
|---|---|
| Legal status |
|
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| ECHA InfoCard | 100.014.764 |
| Chemical and physical data | |
| Formula | C17H23NO |
| Molar mass | 257.377 g·mol−1 |
| |
  (what is this?) (verify) | |
3-Methoxymorphinan is an inactive metabolite of both dextromethorphan and levomethorphan, and has been shown to produce local anesthetic effects.[1] It is the CYP3A4 metabolite of the aforementioned drugs,[2] and is itself metabolized by the liver enzyme CYP2D6.[3]
See also
[edit]References
[edit]- ↑ Hou CH, Tzeng JI, Chen YW, Lin CN, Lin MT, Tu CH, Wang JJ (August 2006). "Dextromethorphan, 3-methoxymorphinan, and dextrorphan have local anaesthetic effect on sciatic nerve blockade in rats". European Journal of Pharmacology. 544 (1–3): 10–16. doi:10.1016/j.ejphar.2006.06.013. PMID 16844109.
- ↑ Min DI, Ku YM, Vichiendilokkul A, Fleckenstein LL (June 1999). "A urine metabolic ratio of dextromethorphan and 3-methoxymorphinan as a probe for CYP3A activity and prediction of cyclosporine clearance in healthy volunteers". Pharmacotherapy. 19 (6): 753–759. doi:10.1592/phco.19.9.753.31536. PMID 10391422. S2CID 32243163.
- ↑ Strauch K, Lutz U, Bittner N, Lutz WK (August 2009). "Dose-response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles". Food and Chemical Toxicology. 47 (8): 1928–1935. doi:10.1016/j.fct.2009.05.004. PMID 19445995.
 | This drug article relating to the nervous system is a stub. You can help Wikipedia by adding missing information. |