NEO1

NEO1
Identifiers
Aliases	NEO1, IGDCC2, NGN, NTN1R2, neogenin 1
External IDs	OMIM: 601907; MGI: 1097159; GeneCards: NEO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X5F, 1X5G, 1X5H, 1X5I, 1X5J, 1X5K, 3P4L, 4UI2
Gene location (Human)
Chr.	Chromosome 15 (human)
End	73,305,205 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	58,943,724 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; internal globus pallidus; ; inferior ganglion of vagus nerve; ; rectum; ; epithelium of colon; ; subthalamic nucleus; ; corpus callosum; ; ventral tegmental area; ; superior vestibular nucleus; ; pylorus;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; epithelium of lens; ; renal corpuscle; ; medullary collecting duct; ; substantia nigra; ; ciliary body; ; ascending aorta; ; Rostral migratory stream; ; aortic valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	co-receptor binding; protein binding; signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane protein complex; plasma membrane; Golgi apparatus; integral component of plasma membrane; membrane; nucleoplasm;
Biological process	positive regulation of BMP signaling pathway; iron ion homeostasis; cell adhesion; nervous system development; axon guidance; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	4756
	18007
	ENSG00000067141
	ENSMUSG00000032340
	Q92859
	P97798
	NM_001172623; NM_001172624; NM_002499
	NM_001042752; NM_008684
	NP_001166094; NP_001166095; NP_002490
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Neogenin is a protein that in humans is encoded by the NEO1 gene.^[5]^[6]

Interactions

NEO1 has been shown to interact with PTK2.^[7] Also Neogenin receptor is pointed as a component of the mechanisms that determine skeletal cell fusion via RGMa (repulsive guidance molecule a) binding. ^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000067141 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032340 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Meyerhardt JA, Look AT, Bigner SH, Fearon ER (April 1997). "Identification and characterization of neogenin, a DCC-related gene". Oncogene. 14 (10): 1129–1136. doi:10.1038/sj.onc.1200935. PMID 9121761.
↑ "Entrez Gene: NEO1 neogenin homolog 1 (chicken)".
↑ Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, et al. (November 2004). "Focal adhesion kinase in netrin-1 signaling". Nature Neuroscience. 7 (11): 1204–1212. doi:10.1038/nn1330. PMID 15494733. S2CID 2901216.
↑ do Carmo Costa A, Copola AG, Carvalho E, Souza C, Nogueira JM, Silva GA, et al. (April 2021). "RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway". In Vitro Cellular & Developmental Biology. Animal. 57 (4): 415–427. doi:10.1007/s11626-021-00555-9. PMID 33748906. S2CID 232311370.

Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ (1995). "Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer". The Journal of Cell Biology. 127 (6 Pt 2): 2009–2020. doi:10.1083/jcb.127.6.2009. PMC 2120299. PMID 7806578.
Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS, Culotti JG, et al. (1996). "Deleted in Colorectal Cancer (DCC) encodes a netrin receptor". Cell. 87 (2): 175–185. doi:10.1016/S0092-8674(00)81336-7. PMID 8861902.
Vielmetter J, Chen XN, Miskevich F, Lane RP, Yamakawa K, Korenberg JR, et al. (1997). "Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23". Genomics. 41 (3): 414–421. doi:10.1006/geno.1997.4688. PMID 9169140.
Wang H, Copeland NG, Gilbert DJ, Jenkins NA, Tessier-Lavigne M (1999). "Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors". The Journal of Neuroscience. 19 (12): 4938–4947. doi:10.1523/JNEUROSCI.19-12-04938.1999. PMC 6782680. PMID 10366627.
Srinivasan K, Strickland P, Valdes A, Shin GC, Hinck L (2003). "Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis". Developmental Cell. 4 (3): 371–382. doi:10.1016/S1534-5807(03)00054-6. PMID 12636918.
Ho SM, Lau KM, Mok SC, Syed V (2003). "Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells". Oncogene. 22 (27): 4243–4256. doi:10.1038/sj.onc.1206437. PMID 12833147.
Matsunaga E, Tauszig-Delamasure S, Monnier PP, Mueller BK, Strittmatter SM, Mehlen P, et al. (2004). "RGM and its receptor neogenin regulate neuronal survival". Nature Cell Biology. 6 (8): 749–755. doi:10.1038/ncb1157. PMID 15258591. S2CID 15433313.
Lee JE, Kim HJ, Bae JY, Kim SW, Park JS, Shin HJ, et al. (2006). "Neogenin expression may be inversely correlated to the tumorigenicity of human breast cancer". BMC Cancer. 5 154. doi:10.1186/1471-2407-5-154. PMC 1322231. PMID 16324219.
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". Journal of Proteome Research. 4 (6): 2070–2080. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000067141 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032340 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Meyerhardt_1997-5] Meyerhardt JA, Look AT, Bigner SH, Fearon ER (April 1997). "Identification and characterization of neogenin, a DCC-related gene". Oncogene. 14 (10): 1129–1136. doi:10.1038/sj.onc.1200935. PMID 9121761.

[entrez-6] "Entrez Gene: NEO1 neogenin homolog 1 (chicken)".

[Ren_2004-7] Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, et al. (November 2004). "Focal adhesion kinase in netrin-1 signaling". Nature Neuroscience. 7 (11): 1204–1212. doi:10.1038/nn1330. PMID 15494733. S2CID 2901216.

[8] Carmo Costa A, Copola AG, Carvalho E, Souza C, Nogueira JM, Silva GA, et al. (April 2021). "RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway". In Vitro Cellular & Developmental Biology. Animal. 57 (4): 415–427. doi:10.1007/s11626-021-00555-9. PMID 33748906. S2CID 232311370.

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Interactions

References

Further reading