// Workers AI · dad joke modeWhat did Unc-13 homolog C say? "I'm hooked on binding.

UNC13C
Identifiers
Aliases	UNC13C, unc-13 homolog C
External IDs	OMIM: 614568; MGI: 2149021; GeneCards: UNC13C
Gene location (Human) Chr. Chromosome 15 (human) Band 15q21.3 Start 53,978,201 bp End 54,628,707 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 D|9 40.8 cM Start 73,386,704 bp End 73,876,248 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte endothelial cell pars reticulata pars compacta cerebellar vermis pons primary visual cortex cerebellar hemisphere Brodmann area 23 right hemisphere of cerebellum Top expressed in globus pallidus pontine nuclei lateral geniculate nucleus lobe of cerebellum cerebellar vermis superior colliculus nucleus accumbens dorsal striatum primary oocyte ventral tegmental area More reference expression data BioGPS n/a
Gene ontology Molecular function diacylglycerol binding metal ion binding calcium ion binding phospholipid binding calmodulin binding syntaxin-1 binding Cellular component cytoplasm presynaptic active zone cell junction plasma membrane synapse presynaptic membrane membrane terminal bouton calyx of Held presynapse parallel fiber to Purkinje cell synapse synaptic vesicle membrane neuromuscular junction presynaptic active zone cytoplasmic component Biological process intracellular signal transduction exocytosis chemical synaptic transmission synaptic vesicle exocytosis negative regulation of synaptic plasticity neuromuscular junction development synaptic vesicle docking synaptic vesicle priming synaptic vesicle maturation synaptic transmission, glutamatergic dense core granule priming presynaptic dense core vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 440279 208898 Ensembl ENSG00000137766 ENSMUSG00000062151 UniProt Q8NB66 Q8K0T7 RefSeq (mRNA) NM_001080534 NM_001329919 NM_001081153 NM_153531 RefSeq (protein) NP_001074003 NP_001316848 NP_001074622 Location (UCSC) Chr 15: 53.98 – 54.63 Mb Chr 9: 73.39 – 73.88 Mb PubMed search
Wikidata
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Unc-13 homolog C (C. elegans) is a protein that, in humans, is encoded by the UNC13C gene.

Further reading

• Uhl GR, Liu QR, Drgon T, Johnson C, Walther D, Rose JE, David SP, Niaura R, Lerman C (2008). "Molecular genetics of successful smoking cessation: convergent genome-wide association study results". Arch. Gen. Psychiatry. 65 (6): 683–93. doi:10.1001/archpsyc.65.6.683. PMC 2430596. PMID 18519826.