// Workers AI · dad joke modeWhat did TraB domain containing 2B say? "I'm bound to help

TRABD2B
Identifiers
Aliases	TRABD2B, TIKI2, TraB domain containing 2B
External IDs	OMIM: 614913; MGI: 3650152; GeneCards: TRABD2B
Gene location (Human)
Chr.	Chromosome 1 (human)
End	47,997,385 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	114,472,295 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; right coronary artery; ; left coronary artery; ; ascending aorta; ; Descending thoracic aorta; ; right auricle of heart; ; human kidney; ; sural nerve; ; right lobe of liver;
	Top expressed in
	myocardium of ventricle; ; interventricular septum; ; human kidney; ; right kidney; ; otolith organ; ; utricle; ; external carotid artery; ; calvaria; ; internal carotid artery; ; aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	Wnt-protein binding; peptidase activity; metalloendopeptidase activity; protein binding; metallopeptidase activity; hydrolase activity; metal ion binding;
Cellular component	integral component of membrane; integral component of organelle membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	negative regulation of Wnt signaling pathway; Wnt signaling pathway; proteolysis; positive regulation of protein oxidation; positive regulation of protein oligomerization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	388630
	666048
	ENSG00000269113
	ENSMUSG00000070867
	A6NFA1
	B1ATG9
	NM_001194986
	NM_001085549
	NP_001181915
	NP_001079018
	Wikidata
View/Edit Human	View/Edit Mouse

TraB domain containing 2B is a protein that in humans is encoded by the TRABD2B gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000269113 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070867 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: TraB domain containing 2B". Retrieved 2018-05-01.

Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Li R, Liu J, Wu H, Liu L, Wang L, Zhang S (July 2014). "TIKI2 suppresses growth of osteosarcoma by targeting Wnt/β-catenin pathway". Mol. Cell. Biochem. 392 (1–2): 109–16. doi:10.1007/s11010-014-2023-5. PMID 24771064. S2CID 10974823.
Zhang X, MacDonald BT, Gao H, Shamashkin M, Coyle AJ, Martinez RV, He X (January 2016). "Characterization of Tiki, a New Family of Wnt-specific Metalloproteases". J. Biol. Chem. 291 (5): 2435–43. doi:10.1074/jbc.M115.677807. PMC 4732225. PMID 26631728.

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