// Workers AI · dad joke modeDoes Serine–tRNA ligase, mitochondrial have friends? It bonds well.

SARS2
Identifiers
Aliases	SARS2, SARS, SARSM, SERS, SYS, SerRS, SerRSmt, mtSerRS, seryl-tRNA synthetase 2, mitochondrial
External IDs	OMIM: 612804; MGI: 1919234; GeneCards: SARS2
Enzyme activity
Gene location (Human)
Chr.	Chromosome 19 (human)
End	38,930,763 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	28,453,296 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right lobe of thyroid gland; ; right adrenal cortex; ; left lobe of thyroid gland; ; right lobe of liver; ; mucosa of transverse colon; ; left adrenal gland; ; left adrenal cortex; ; pituitary gland; ; primary visual cortex;
	Top expressed in
	epiblast; ; soleus muscle; ; Gonadal ridge; ; yolk sac; ; embryo; ; muscle of thigh; ; embryo; ; maxillary prominence; ; thoracic diaphragm; ; intercostal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; nucleotide binding; ligase activity; ATP binding; serine-tRNA ligase activity; RNA binding;
Cellular component	cytoplasm; mitochondrial matrix; mitochondrion;
Biological process	tRNA aminoacylation for protein translation; protein biosynthesis; seryl-tRNA aminoacylation; selenocysteinyl-tRNA(Sec) biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	54938
	71984
	ENSG00000104835; ENSG00000283104
	ENSMUSG00000070699
	Q9NP81
	Q9JJL8
	NM_017827; NM_001145901
	NM_023637
	NP_001139373; NP_060297
	NP_076126
	Wikidata
View/Edit Human	View/Edit Mouse

Serine–tRNA ligase, mitochondrial, also called seryl-tRNA synthetase 2, mitochondrial, is an enzyme that in humans is encoded by the SARS2 gene.^[5]^[6] Like serine–tRNA ligase, cytoplasmic, this enzyme functions as a serine–tRNA ligase.^[7]

References

1 2 3 ENSG00000283104 GRCh38: Ensembl release 89: ENSG00000104835, ENSG00000283104 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070699 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yokogawa T, Shimada N, Takeuchi N, Benkowski L, Suzuki T, Omori A, Ueda T, Nishikawa K, Spremulli LL, Watanabe K (Aug 2000). "Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase". J Biol Chem. 275 (26): 19913–20. doi:10.1074/jbc.M908473199. PMID 10764807.
↑ "Entrez Gene: SARS2 seryl-tRNA synthetase 2, mitochondrial".
↑ EC 6.1.11

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1) 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Müller T, Deschauer M, Neudecker S, Zierz S (2007). "Late-onset mitochondrial myopathy with dystrophic changes due to a G7497A mutation in the mitochondrial tRNA(Ser(UCN)) gene". Acta Neuropathol. 110 (4): 426–30. doi:10.1007/s00401-005-1063-z. PMID 16133542. S2CID 23568019.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ihalamulla RL, Liyanage CP, Karunaweera ND (2004). "A simple device to maintain in vitro cultures of Leishmania in tropical countries". Trans. R. Soc. Trop. Med. Hyg. 98 (5): 315–7. doi:10.1016/j.trstmh.2003.10.004. PMID 15109557.
Gibbons WJ, Yan Q, Li R, et al. (2004). "Genomic organization, expression, and subcellular localization of mouse mitochondrial seryl-tRNA synthetase". Biochem. Biophys. Res. Commun. 317 (3): 774–8. Bibcode:2004BBRC..317..774G. doi:10.1016/j.bbrc.2004.03.113. PMID 15081407.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Casas C, Ribera J, Esquerda JE (2001). "Antibodies against c-Jun N-terminal peptide cross-react with neo-epitopes emerging after caspase-mediated proteolysis during apoptosis". J. Neurochem. 77 (3): 904–15. doi:10.1046/j.1471-4159.2001.00314.x. PMID 11331419. S2CID 27427659.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000283104 GRCh38: Ensembl release 89: ENSG00000104835, ENSG00000283104 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070699 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10764807-5] Yokogawa T, Shimada N, Takeuchi N, Benkowski L, Suzuki T, Omori A, Ueda T, Nishikawa K, Spremulli LL, Watanabe K (Aug 2000). "Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase". J Biol Chem. 275 (26): 19913–20. doi:10.1074/jbc.M908473199. PMID 10764807.

[entrez-6] "Entrez Gene: SARS2 seryl-tRNA synthetase 2, mitochondrial".

[7] EC 6.1.11

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References

Further reading