// Workers AI · dad joke modeWhat did the NEURL say? I'm a little "off" nerve.

NEURL1
Identifiers
Aliases	NEURL1, NEUR1, NEURL, RNF67, bA416N2.1, neu, neu-1, neuralized E3 ubiquitin protein ligase 1
External IDs	OMIM: 603804; MGI: 1334263; GeneCards: NEURL1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 10 (human)
End	103,592,546 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	47,247,880 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; right hemisphere of cerebellum; ; gastrocnemius muscle; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; prefrontal cortex; ; nucleus accumbens; ; Brodmann area 9; ; amygdala;
	Top expressed in
	muscle of thigh; ; superior frontal gyrus; ; triceps brachii muscle; ; primary visual cortex; ; temporal muscle; ; dentate gyrus of hippocampal formation granule cell; ; sternocleidomastoid muscle; ; skeletal muscle tissue; ; digastric muscle; ; vastus lateralis muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	translation factor activity, non-nucleic acid binding; ubiquitin protein ligase activity; metal ion binding; ubiquitin-protein transferase activity; transferase activity;
Cellular component	cytoplasm; perikaryon; postsynaptic membrane; cell projection; membrane; postsynaptic density; plasma membrane; dendritic spine; synapse; cell junction; dendrite; perinuclear region of cytoplasm; apical dendrite;
Biological process	Notch signaling pathway; flagellated sperm motility; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of dendritic spine development; protein monoubiquitination; nervous system development; sperm axoneme assembly; positive regulation of synapse maturation; brain development; positive regulation of long-term neuronal synaptic plasticity; protein ubiquitination; positive regulation of apoptotic process; cellular response to amino acid stimulus; lactation; skeletal muscle tissue development; positive regulation of filopodium assembly; regulation of translation; negative regulation of cell population proliferation; negative regulation of Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9148
	18011
	ENSG00000107954
	ENSMUSG00000006435
	O76050
	Q923S6
	NM_004210
	NM_001163480; NM_021360
	NP_004201
	NP_001156952; NP_067335
	Wikidata
View/Edit Human	View/Edit Mouse

Neuralized-like protein 1 is a protein that in humans is encoded by the NEURL1 gene (previously NEURL).^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000107954 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006435 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nakamura H, Yoshida M, Tsuiki H, Ito K, Ueno M, Nakao M, Oka K, Tada M, Kochi M, Kuratsu J, Ushio Y, Saya H (Apr 1998). "Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region". Oncogene. 16 (8): 1009–19. doi:10.1038/sj.onc.1201618. PMID 9519875.
↑ "Entrez Gene: NEURL neuralized homolog (Drosophila)".

Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Timmusk T, Palm K, Belluardo N, et al. (2002). "Dendritic localization of mammalian neuralized mRNA encoding a protein with transcription repression activities". Mol. Cell. Neurosci. 20 (4): 649–68. doi:10.1006/mcne.2002.1148. PMID 12213446. S2CID 25771738.
Pavlopoulos E, Kokkinaki M, Koutelou E, et al. (2002). "Cloning, chromosomal organization and expression analysis of Neurl, the mouse homolog of Drosophila melanogaster neuralized gene". Biochim. Biophys. Acta. 1574 (3): 375–82. doi:10.1016/s0167-4781(01)00330-x. PMID 11997106.
Vollrath B, Pudney J, Asa S, et al. (2001). "Isolation of a Murine Homologue of the Drosophila neuralized Gene, a Gene Required for Axonemal Integrity in Spermatozoa and Terminal Maturation of the Mammary Gland". Mol. Cell. Biol. 21 (21): 7481–94. doi:10.1128/MCB.21.21.7481-7494.2001. PMC 99920. PMID 11585928.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000107954 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006435 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9519875-5] Nakamura H, Yoshida M, Tsuiki H, Ito K, Ueno M, Nakao M, Oka K, Tada M, Kochi M, Kuratsu J, Ushio Y, Saya H (Apr 1998). "Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region". Oncogene. 16 (8): 1009–19. doi:10.1038/sj.onc.1201618. PMID 9519875.

[entrez-6] "Entrez Gene: NEURL neuralized homolog (Drosophila)".

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// Workers AI · dad joke modeWhat did the NEURL say? I'm a little "off" nerve.

See also

References

Further reading