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GNPAT
Identifiers
Aliases	GNPAT, Gnpat, AU019525, D1Ertd819e, DHAPAT, DAP-AT, DAPAT, RCDP2, glyceronephosphate O-acyltransferase
External IDs	OMIM: 602744; MGI: 1343460; GeneCards: GNPAT
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	231,277,973 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	125,616,796 bp
RNA expression pattern
	Top expressed in
	glutes; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; deltoid muscle; ; triceps brachii muscle; ; vastus lateralis muscle; ; gastrocnemius muscle; ; thoracic diaphragm; ; sperm; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	tail of embryo; ; spermatid; ; muscle of thigh; ; genital tubercle; ; spermatocyte; ; neural layer of retina; ; seminiferous tubule; ; yolk sac; ; intercostal muscle; ; cardiac muscle tissue of left ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	signaling receptor binding; transferase activity; palmitoyl-CoA hydrolase activity; catalytic activity; O-acyltransferase activity; acyltransferase activity; glycerone-phosphate O-acyltransferase activity;
Cellular component	mitochondrion; peroxisome; membrane; peroxisomal matrix; peroxisomal membrane; cytosol; mitochondrial membranes;
Biological process	membrane organization; myelination; glycerophospholipid metabolic process; phosphatidic acid biosynthetic process; metabolism; response to starvation; response to fatty acid; synapse assembly; cerebellum morphogenesis; response to nutrient; paranodal junction assembly; ether lipid biosynthetic process; cellular lipid metabolic process; protein targeting to peroxisome; fatty acid metabolic process; phospholipid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8443
	14712
	ENSG00000116906
	ENSMUSG00000031985
	O15228
	P98192
	NM_014236; NM_001316350
	NM_010322
	NP_001303279; NP_055051
	NP_034452
	Wikidata
View/Edit Human	View/Edit Mouse

Glyceronephosphate O-acyltransferase is an enzyme associated with rhizomelic chondrodysplasia punctata type 2.^[5]

The gene encoding it, GNPAT, is located on chromosome 1 on the plus strand. The gene C1orf131 is located directly upstream of it, and the closest downstream gene is EXOC8.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116906 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031985 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Velišek J, Cejpek K (2011). "Biosynthesis of Food Constituents: Lipids. 2. Triacylglycerols, Glycerophospholipids, and Glyceroglycolipids". Czech J. Food Sci. 24 (6): 241–254. doi:10.17221/3321-CJFS. S2CID 73576606.
↑ "GNPAT glyceronephosphate O-acyltransferase [ Homo sapiens (human) ]". Gene. National Center for Biotechnology Information. 26 January 2024. Gene ID 8443. Retrieved 27 February 2024.

External links

glycerone-phosphate+O-acyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This EC 2.3 enzyme-related article is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116906 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031985 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Velišek J, Cejpek K (2011). "Biosynthesis of Food Constituents: Lipids. 2. Triacylglycerols, Glycerophospholipids, and Glyceroglycolipids". Czech J. Food Sci. 24 (6): 241–254. doi:10.17221/3321-CJFS. S2CID 73576606.

[6] "GNPAT glyceronephosphate O-acyltransferase [ Homo sapiens (human) ]". Gene. National Center for Biotechnology Information. 26 January 2024. Gene ID 8443. Retrieved 27 February 2024.

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v t e Peroxisomal and lysosomal proteins
Enzymes	Mevalonate kinase Catalase Acetyl-CoA C-acyltransferase Glyceronephosphate O-acyltransferase Alkylglycerone phosphate synthase Phytanoyl-CoA dioxygenase HSD17B4 AMACR
Transporters	SLC27A2
Structure/Peroxin	PEX1 PEX2 PEX3 PEX5 PEX6 PEX7 PEX10 PEX11A PEX11B PEX11G PEX12 PEX13 PEX14 PEX16 PEX19 PEX26
LAMP	CD68 LAMP1 LAMP2 LAMP3
see also intermediates, disorders

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)