NALF1

NALF1
Identifiers
Aliases	NALF1, family with sequence similarity 155 member A, NLF-1, NALCN channel auxiliary factor 1, FAM155A
External IDs	MGI: 2142765; GeneCards: NALF1
Gene location (Human) Chr. Chromosome 13 (human) Band 13q33.3 Start 107,163,510 bp End 107,867,496 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 A1.1 Start 9,255,902 bp End 9,821,161 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 buccal mucosa cell middle temporal gyrus amniotic fluid lateral nuclear group of thalamus primary visual cortex postcentral gyrus entorhinal cortex superior frontal gyrus Top expressed in subiculum piriform cortex dorsomedial hypothalamic nucleus ventral tegmental area mammillary body ventromedial nucleus medial dorsal nucleus medial geniculate nucleus suprachiasmatic nucleus pineal gland More reference expression data BioGPS n/a
Gene ontology Molecular function stretch-activated, cation-selective, calcium channel activity Cellular component membrane integral component of membrane plasma membrane Biological process calcium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 728215 270028 Ensembl ENSG00000204442 ENSMUSG00000079157 UniProt B1AL88 Q8CCS2 RefSeq (mRNA) NM_001080396 NM_173446 NM_001347127 RefSeq (protein) NP_001073865 NP_001334056 NP_775622 Location (UCSC) Chr 13: 107.16 – 107.87 Mb Chr 8: 9.26 – 9.82 Mb PubMed search
Wikidata
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NALCN channel auxiliary factor 1 is a protein that in humans is encoded by the NALF1 gene (previously FAM155A). The NALF1 protein is a subunit of the NALCN channelosome complex, which is a voltage-gated ion channel that regulates the resting potential of cell membranes, which controls neuronal excitability.

See also

• NALF2

Further reading

• Anney RJ, Lasky-Su J, O'Dúshláine C, Kenny E, Neale BM, Mulligan A, et al. (December 2008). "Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 147B (8): 1369–1378. doi:10.1002/ajmg.b.30871. PMID 18951430. S2CID 30325260.
• Cross-Disorder Group of the Psychiatric Genomics Consortium (April 2013). "Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis". Lancet. 381 (9875): 1371–1379. doi:10.1016/S0140-6736(12)62129-1. PMC 3714010. PMID 23453885.
• Wang K, Zhang H, Bloss CS, Duvvuri V, Kaye W, Schork NJ, et al. (September 2011). "A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa". Molecular Psychiatry. 16 (9): 949–959. doi:10.1038/mp.2010.107. PMC 3859494. PMID 21079607.
• Li SH, McInnis MG, Margolis RL, Antonarakis SE, Ross CA (June 1993). "Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms". Genomics. 16 (3): 572–579. doi:10.1006/geno.1993.1232. PMID 8325628.
• Terracciano A, Tanaka T, Sutin AR, Sanna S, Deiana B, Lai S, et al. (November 2010). "Genome-wide association scan of trait depression". Biological Psychiatry. 68 (9): 811–817. doi:10.1016/j.biopsych.2010.06.030. PMC 2955852. PMID 20800221.