// Workers AI · dad joke modeWhat did CREB say to ATF? "Bind with me.

CREBZF
Identifiers
Aliases	CREBZF, SMILE, ZF, CREB/ATF bZIP transcription factor
External IDs	OMIM: 606444; MGI: 2675296; HomoloGene: 10926; GeneCards: CREBZF; OMA:CREBZF - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	85,682,908 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	90,097,202 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; left ovary; ; right ovary; ; body of uterus; ; right hemisphere of cerebellum; ; cardia; ; ventricular zone; ; right lung; ; canal of the cervix; ; left lobe of thyroid gland;
	Top expressed in
	neural layer of retina; ; ventricular zone; ; genital tubercle; ; cerebellar cortex; ; thymus; ; tail of embryo; ; spermatocyte; ; lobe of cerebellum; ; ganglionic eminence; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; protein binding; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; mitochondrion;
Biological process	response to virus; negative regulation of gene expression, epigenetic; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; regulation of DNA-binding transcription factor activity; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	58487
	233490
	ENSG00000137504
	ENSMUSG00000051451
	Q9NS37
	Q91ZR3
	NM_001039618; NM_021212
	NM_145151
	NP_001034707
	NP_660133
	Wikidata
View/Edit Human	View/Edit Mouse

CREB/ATF bZIP transcription factor is a protein that in humans is encoded by the CREBZF gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000137504 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051451 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CREB/ATF bZIP transcription factor". Retrieved 2017-07-20.

Misra V, Rapin N, Akhova O, Bainbridge M, Korchinski P (2005). "Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman". J. Biol. Chem. 280 (15): 15257–66. doi:10.1074/jbc.M500728200. PMID 15705566.
Akhova O, Bainbridge M, Misra V (2005). "The neuronal host cell factor-binding protein Zhangfei inhibits herpes simplex virus replication". J. Virol. 79 (23): 14708–18. doi:10.1128/JVI.79.23.14708-14718.2005. PMC 1287584. PMID 16282471.
Hogan MR, Cockram GP, Lu R (2006). "Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element". FEBS Lett. 580 (1): 58–62. Bibcode:2006FEBSL.580...58H. doi:10.1016/j.febslet.2005.11.046. PMID 16343488. S2CID 34571628.
Xie YB, Lee OH, Nedumaran B, Seong HA, Lee KM, Ha H, Lee IK, Yun Y, Choi HS (2008). "SMILE, a new orphan nuclear receptor SHP-interacting protein, regulates SHP-repressed estrogen receptor transactivation". Biochem. J. 416 (3): 463–73. doi:10.1042/BJ20080782. PMID 18657049.
Valderrama X, Rapin N, Verge VM, Misra V (2009). "Zhangfei induces the expression of the nerve growth factor receptor, trkA, in medulloblastoma cells and causes their differentiation or apoptosis". J. Neurooncol. 91 (1): 7–17. doi:10.1007/s11060-008-9682-6. PMID 18719857. S2CID 25560950.
Valderrama X, Rapin N, Verge VM, Misra V (2009). "Zhangfei induces the expression of the nerve growth factor receptor, trkA, in medulloblastoma cells and causes their differentiation or apoptosis". J. Neurooncol. 91 (1): 7–17. doi:10.1007/s11060-008-9682-6. PMID 18719857. S2CID 25560950.
Valderrama X, Rapin N, Misra V (2008). "Zhangfei, a novel regulator of the human nerve growth factor receptor, trkA". J. Neurovirol. 14 (5): 425–36. doi:10.1080/13550280802275904. PMID 19016376. S2CID 20896925.
Xie YB, Park JH, Kim DK, Hwang JH, Oh S, Park SB, Shong M, Lee IK, Choi HS (2009). "Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation". J. Biol. Chem. 284 (42): 28762–74. doi:10.1074/jbc.M109.034165. PMC 2781422. PMID 19690166.
Racapé M, Duong Van Huyen JP, Danger R, Giral M, Bleicher F, Foucher Y, Pallier A, Pilet P, Tafelmeyer P, Ashton-Chess J, Dugast E, Pettré S, Charreau B, Soulillou JP, Brouard S (2011). "The involvement of SMILE/TMTC3 in endoplasmic reticulum stress response". PLOS ONE. 6 (5) e19321. Bibcode:2011PLoSO...619321R. doi:10.1371/journal.pone.0019321. PMC 3095597. PMID 21603654.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000137504 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051451 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CREB/ATF bZIP transcription factor". Retrieved 2017-07-20.

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References

Further reading