// Workers AI · dad joke modeWhat did ABHD16A gene say? I'm a 'cut' above the rest.
| ABHD16A | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | ABHD16A, BAT5, D6S82E, NG26, PP199, abhydrolase domain containing 16A, hBAT5, abhydrolase domain containing 16A, phospholipase, SPG86 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 142620; MGI: 99476; GeneCards: ABHD16A | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Phosphatidylserine lipase ABHD16A is an enzyme that in humans is encoded by the gene ABHD16A (previously BAT5).[5][6][7] This enzyme is a monoglyceride lipase (EC 3.1.1.23), meaning it helps break down monoglyceride into glycerol and a fatty acid, but unlike many conventional lipases, it doesn't act on triglycerides or diglycerides.[8] As its name suggests, it is also predicted to be a phosphatidylserine lipase, meaning it helps convert phosphatidylserine into lysophosphatidylserine (LPS).[8]
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity.[7]
Gene
[edit]Human Bat5 (ABHD16A) is located on chromosome 6. Mice Bat5 (ABHD 16A) is located between TNF and Heat shock protein near the Ck2b protein kinase gene.[9]
BAT5 is highly conserved in human, mice and other mammals.[10] It is found to be expressed in multiple different tissue cells. According to molecular evolutionary genetic analysis, in comparison of 13 mammalian species, it was denoted that the differences in amino acid sequence length are due to splicing in the post transcriptional processing of mRNA.[9]
Structure
[edit]
The human BAT5 protein (also known as ABHD16A) is 558 amino acid residues long. It was first identified in 1992 in the gene domains of TNF alpha and TNF beta. The BAT5 (ABHD 16A) proteins found in different species have varying lengths.
_compared_to_mice_(m).png)
BAT5 in humans and mice has been found to be around 63 kDA.
Research
[edit]In previous studies, the connection of malformations in the BAT5 (ABHD 16A) protein had yet to be linked to noticeable human diseases. Yet recent studies show that the BAT5 (ABHD 16A) has been linked to neurological, immune regulation, Kawasaki's disease and coronary artery disease.[9]
The BAT5 (ABHD 16A) protein has been found to encode a majority of phosphatidylserine (PS) lipase in the brain. PS lipase synthesizes lysophosphatidylserine which is an important signaling lipid that functions in the mammalian central nervous system.[11] According to a cohort study, relating malformations of the BAT5 (ABHD 16A) protein to human disease, the affected individuals presented with intellectual disability and progressive spasticity of the upper and lower limbs.[11]
References
[edit]- 1 2 3 ENSG00000231488, ENSG00000204427, ENSG00000235676, ENSG00000230475, ENSG00000206403, ENSG00000224552 GRCh38: Ensembl release 89: ENSG00000236063, ENSG00000231488, ENSG00000204427, ENSG00000235676, ENSG00000230475, ENSG00000206403, ENSG00000224552 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000007036 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Spies T, Blanck G, Bresnahan M, Sands J, Strominger JL (February 1989). "A new cluster of genes within the human major histocompatibility complex". Science. 243 (4888). New York, N.Y.: 214–217. Bibcode:1989Sci...243..214S. doi:10.1126/science.2911734. PMID 2911734.
- ↑ Spies T, Bresnahan M, Strominger JL (December 1989). "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proceedings of the National Academy of Sciences of the United States of America. 86 (22): 8955–8958. Bibcode:1989PNAS...86.8955S. doi:10.1073/pnas.86.22.8955. PMC 298409. PMID 2813433.
- 1 2 "Entrez Gene: BAT5 HLA-B associated transcript 5".
- 1 2 "O95870 · Abhga_human". uniprot.org. UniProt consortium. Retrieved 2026-09-08.
- 1 2 3 Xu J, Gu W, Ji K, Xu Z, Zhu H, Zheng W (May 2018). "Sequence analysis and structure prediction of ABHD16A and the roles of the ABHD family members in human disease". Open Biology. 8 (5) 180017. doi:10.1098/rsob.180017. PMC 5990648. PMID 29794032.
- ↑ Savinainen JR, Patel JZ, Parkkari T, Navia-Paldanius D, Marjamaa JJ, Laitinen T, et al. (2014). "Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A)". PLOS ONE. 9 (10) e109869. Bibcode:2014PLoSO...9j9869S. doi:10.1371/journal.pone.0109869. PMC 4188605. PMID 25290914.
- 1 2 Lemire G, Ito YA, Marshall AE, Chrestian N, Stanley V, Brady L, et al. (October 2021). "ABHD16A deficiency causes a complicated form of hereditary spastic paraplegia associated with intellectual disability and cerebral anomalies". American Journal of Human Genetics. 108 (10): 2017–2023. doi:10.1016/j.ajhg.2021.09.005. PMC 8546048. PMID 34587489.
External links
[edit]- Human ABHD16A genome location and ABHD16A gene details page in the UCSC Genome Browser.
Further reading
[edit]- Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, et al. (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–569. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
- Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, et al. (December 2003). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Research. 13 (12): 2621–2636. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
- Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (January 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–167. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Research. 14 (7): 1315–1323. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
- Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, et al. (November 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15724–15729. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
 | This protein-related article is a stub. You can help Wikipedia by adding missing information. |