Histone H4 transcription factor

HINFP
Identifiers
Aliases	HINFP, HiNF-P, MIZF, ZNF743, histone H4 transcription factor
External IDs	OMIM: 607099; MGI: 2429620; GeneCards: HINFP
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.2 Start 44,203,737 bp End 44,216,968 bp
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in neural layer of retina ascending aorta aortic valve granulocyte Rostral migratory stream spermatocyte yolk sac ventricular zone tail of embryo zygote BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription coactivator activity histone binding metal ion binding protein binding nucleic acid binding enzyme binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific chromatin binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component Cajal body nucleoplasm nucleolus nucleus Biological process regulation of transcription, DNA-templated establishment of protein localization DNA damage checkpoint signaling regulation of transcription involved in G1/S transition of mitotic cell cycle negative regulation of gene expression transcription, DNA-templated regulation of gene expression myoblast differentiation negative regulation of transcription, DNA-templated DNA repair negative regulation of transcription by RNA polymerase II in utero embryonic development positive regulation of gene expression positive regulation of transcription, DNA-templated G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 25988 102423 Ensembl ENSG00000172273 ENSMUSG00000032119 UniProt Q9BQA5 Q8K1K9 RefSeq (mRNA) NM_001243259 NM_015517 NM_198971 NM_172162 RefSeq (protein) NP_001230188 NP_056332 NP_945322 NP_001338886 NP_001338887 NP_001338888 NP_001338889 NP_001338890 NP_001338891 NP_001338892 NP_001338893 NP_001338894 NP_001338895 NP_001338898 NP_001338900 NP_001338901 NP_001338903 NP_751894 NP_001391993 NP_001391994 NP_001391995 Location (UCSC) n/a Chr 9: 44.2 – 44.22 Mb PubMed search
Wikidata
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Histone H4 transcription factor (or HiNF-P) is a protein that in humans is encoded by the HINFP gene (previously MIZF). HiNF-P/HINFP stand for "histone nuclear factor P".

Function

HiNF-P is a protein that binds to a highly conserved DNA motif found in most histone H4 genes. HiNF-P activates H4 gene expression through interactions with the CDK2 substrate NPAT which is localized in Histone Locus Bodies. HiNF-P was independently described as a protein called "MBD2 interacting zinc finger protein" (MIZF). MIZF was reported to interact with methyl-CpG-binding protein-2 (MBD2; MIM 603547), a component of the MeCP1 histone deacetylase (HDAC) complex. MIZF is thought to play a role in DNA methylation and transcription repression.[supplied by OMIM]

Interactions

One key partner protein of HiNF-P is NPAT, a CDK2 substrate that localizes to Histone Locus Bodies. HiNF-P has been reported to interact with Methyl-CpG-binding domain protein 2 and DHX9.

Further reading

• Medina R, van der Deen M, Miele-Chamberland A, Xie RL, van Wijnen AJ, Stein JL, Stein GS (2007). "The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes". Cancer Res. 67 (21): 10334–42. doi:10.1158/0008-5472.CAN-07-1560. PMID 17974976.
• Mitra P, Xie R, Harper JW, Stein JL, Stein GS, van Wijnen AJ (2007). "HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription". J. Cell. Biochem. 101 (1): 181–91. doi:10.1002/jcb.21157. PMID 17163457. S2CID 23552843.
• Fukushige S, Kondo E, Gu Z, Suzuki H, Horii A (2006). "RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression". Biochem. Biophys. Res. Commun. 351 (1): 85–92. doi:10.1016/j.bbrc.2006.10.005. PMID 17049487.
• Pulukuri SM, Rao JS (2006). "CpG island promoter methylation and silencing of 14-3-3sigma gene expression in LNCaP and Tramp-C1 prostate cancer cell lines is associated with methyl-CpG-binding protein MBD2". Oncogene. 25 (33): 4559–72. doi:10.1038/sj.onc.1209462. PMC 1526774. PMID 16786000.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Miele A, Braastad CD, Holmes WF, Mitra P, Medina R, Xie R, Zaidi SK, Ye X, Wei Y, Harper JW, van Wijnen AJ, Stein JL, Stein GS (2005). "HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition". Mol. Cell. Biol. 25 (14): 6140–53. doi:10.1128/MCB.25.14.6140-6153.2005. PMC 1168814. PMID 15988025.
• Sekimata M, Homma Y (2004). "Regulation of Rb gene expression by an MBD2-interacting zinc finger protein MIZF during myogenic differentiation". Biochem. Biophys. Res. Commun. 325 (3): 653–9. doi:10.1016/j.bbrc.2004.10.090. PMID 15541338.
• Sekimata M, Homma Y (2004). "Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF". Nucleic Acids Res. 32 (2): 590–7. doi:10.1093/nar/gkh249. PMC 373363. PMID 14752047.
• Mitra P, Xie RL, Medina R, Hovhannisyan H, Zaidi SK, Wei Y, Harper JW, Stein JL, van Wijnen AJ, Stein GS (2003). "Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase". Mol. Cell. Biol. 23 (22): 8110–23. doi:10.1128/MCB.23.22.8110-8123.2003. PMC 262391. PMID 14585971.