Chymotrypsinogen B1

CTRB1
Identifiers
Aliases	CTRB1, CTRB, chymotrypsinogen B1
External IDs	OMIM: 118890; MGI: 88559; GeneCards: CTRB1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 16 (human)
End	75,226,338 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	112,417,642 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; duodenum; ; fundus; ; right coronary artery; ; ectocervix; ; right uterine tube; ; canal of the cervix; ; testicle; ; right adrenal gland;
	Top expressed in
	pyloric antrum; ; islet of Langerhans; ; migratory enteric neural crest cell; ; cardiac muscle tissue of left ventricle; ; plantaris muscle; ; extensor digitorum longus muscle; ; interventricular septum; ; duodenum; ; corneal stroma; ; sexually immature organism;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity;
Cellular component	extracellular region; extracellular space;
Biological process	digestion; cobalamin metabolic process; extracellular matrix disassembly; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	1504
	66473
	ENSG00000168925; ENSG00000285346
	ENSMUSG00000031957
	P17538
	Q9CR35
	NM_001906; NM_001329190
	NM_025583
	NP_001316119; NP_001897
	NP_079859
	Wikidata
View/Edit Human	View/Edit Mouse

Chymotrypsinogen B1 (or sometimes just Chymotrypsinogen B) is a protein that in humans is encoded by the CTRB1 gene.^[5] Similar to its paralog chymotrypsinogen B2, chymotrypsiongen B1 is an inactive precursor for an enzyme which is an isozyme of chymotrypsin.^[6] It is secreted by the acinar cells of the pancreas into the small intestines as part of pancreatic juice, where it is activated.^[5]^[7] After activation it functions as a protease which is involved in breaking down other proteins as part of digestion.^[5]

Medical significance

The CTRB1 and CTRB2 genes are located near each other on chromosome 16.^[5] In some populations there is an inversion which causes certain parts of each gene to be swapped, which has been associated with an increased risk of chronic pancreatitis.^[5]

References

1 2 3 ENSG00000285346 GRCh38: Ensembl release 89: ENSG00000168925, ENSG00000285346 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031957 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 4 5 "Entrez Gene: Chymotrypsinogen B1". Retrieved 2026-09-01.
↑ "P17538 · CTRB1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-09-01.
↑ Pandol SJ (2010). "Anatomy". The Exocrine Pancreas. Morgan & Claypool Life Science.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000285346 GRCh38: Ensembl release 89: ENSG00000168925, ENSG00000285346 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031957 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 3 4 5 "Entrez Gene: Chymotrypsinogen B1". Retrieved 2026-09-01.

[6] "P17538 · CTRB1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-09-01.

[pandol2010-7] Pandol SJ (2010). "Anatomy". The Exocrine Pancreas. Morgan & Claypool Life Science.

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Medical significance

References