// Workers AI · dad joke modeWhy did Triethylenemelamine go to therapy? It had a bonding issue.
(Redirected from Tretamine)
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| ECHA InfoCard | 100.000.076 |
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| Formula | C9H12N6 |
| Molar mass | 204.237 g·mol−1 |
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Triethylenemelamine (abbreviated TEM, also called Tretamine) is a drug used in chemotherapy.[1]
It is a mutagenic chemical because it is an alkylating antineoplastic agent, a trifunctional alkylating agent that has three reactive groups that enable it to bind covalently to DNA at three distinct sites. As a result, TEM can cause chromatid aberrations in cell models.[2] It was one of the first compounds used for chemical mutagenesis in laboratory mice, with the impact on mutagenesis measured by the specific-locus test by Bruce Cattanach.[3]
See also
[edit]References
[edit]- ↑ Wong JR, Morton LM, Tucker MA, Abramson DH, Seddon JM, Sampson JN, Kleinerman RA (October 2014). "Risk of subsequent malignant neoplasms in long-term hereditary retinoblastoma survivors after chemotherapy and radiotherapy". Journal of Clinical Oncology. 32 (29): 3284–3290. doi:10.1200/JCO.2013.54.7844. PMC 4178525. PMID 25185089.
- ↑ Luippold HE, Gooch PC, Brewen JG (February 1978). "The production of chromosome aberrations in various mammalian cells by triethylenemelamine". Genetics. 88 (2): 317–326. doi:10.1093/genetics/88.2.317. PMC 1213803. PMID 565312.
- ↑ Cattanach, B. M. (1966). "Chemically induced mutations in mice". Mutation Research. 3 (4): 346–353. doi:10.1016/0027-5107(66)90041-8. PMID 5969214.
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