Tyrosyl-DNA phosphodiesterase 2

TDP2
Identifiers
Aliases	TDP2, AD022, EAP2, EAPII, TTRAP, dJ30M3.3, htyrosyl-DNA phosphodiesterase 2
External IDs	OMIM: 605764; MGI: 1860486; GeneCards: TDP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5J3S, 5INO, 5J3P
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.3 Start 24,649,979 bp End 24,666,930 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 A3.1|13 10.7 cM Start 25,015,662 bp End 25,026,136 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of sigmoid colon mucosa of ileum rectum duodenum mucosa of transverse colon gonad palpebral conjunctiva kidney tubule islet of Langerhans Top expressed in otic placode saccule otic vesicle primitive streak tail of embryo abdominal wall atrioventricular valve epiblast ciliary body maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding single-stranded DNA binding nuclease activity protein binding 5'-tyrosyl-DNA phosphodiesterase activity manganese ion binding transcription corepressor activity magnesium ion binding tyrosyl-RNA phosphodiesterase activity hydrolase activity Cellular component cytoplasm PML body nucleolus nucleus nucleoplasm aggresome nuclear body Biological process cell surface receptor signaling pathway double-strand break repair DNA repair nucleic acid phosphodiester bond hydrolysis cellular response to DNA damage stimulus negative regulation of nucleic acid-templated transcription neuron development Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 51567 56196 Ensembl ENSG00000111802 ENSMUSG00000035958 UniProt O95551 Q9JJX7 RefSeq (mRNA) NM_016614 NM_019551 RefSeq (protein) NP_057698 NP_062424 Location (UCSC) Chr 6: 24.65 – 24.67 Mb Chr 13: 25.02 – 25.03 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Tyrosyl-DNA phosphodiesterase 2 is an enzyme that in humans is encoded by the gene TDP2 (previously TTRAP). The TDP2 protein functions as a DNA repair enzyme by removing covalent adducts from DNA. It functions in a similar role to the TDP1 enzyme, but it preferentially acts on 5'-phosphodiester bonds, while TDP1 is the faster and more efficient enzyme for 3'-phosphodiester bonds.

This protein is a member of a superfamily of divalent cation-dependent phosphodiesterases. It associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.

Interactions

TTRAP has been shown to interact with ETS1, TNFRSF1B and CD40.

Further reading

• Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE (2000). "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation". J. Biol. Chem. 275 (24): 18586–93. doi:10.1074/jbc.M000531200. PMID 10764746.
• Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Pei H, Yordy JS, Leng Q, Zhao Q, Watson DK, Li R (2003). "EAPII interacts with ETS1 and modulates its transcriptional function". Oncogene. 22 (18): 2699–709. doi:10.1038/sj.onc.1206374. PMID 12743594. S2CID 35966215.
• Lee BH, Yoshimatsu K, Maeda A, Ochiai K, Morimatsu M, Araki K, Ogino M, Morikawa S, Arikawa J (2003). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules". Virus Res. 98 (1): 83–91. doi:10.1016/j.virusres.2003.09.001. PMID 14609633.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Luciano M, Lind PA, Duffy DL, Castles A, Wright MJ, Montgomery GW, Martin NG, Bates TC (2007). "A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability". Biol. Psychiatry. 62 (7): 811–7. doi:10.1016/j.biopsych.2007.03.007. PMID 17597587. S2CID 11334660.