NSA2

NSA2
Identifiers
Aliases	NSA2, CDK105, HCL-G1, HCLG1, HUSSY29, TINP1, HUSSY-29, ribosome biogenesis homolog, NSA2 ribosome biogenesis factor
External IDs	OMIM: 612497; MGI: 1913883; GeneCards: NSA2
Gene location (Human)
Chr.	Chromosome 5 (human)
End	74,780,113 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	97,274,445 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; parotid gland; ; skin of thigh; ; skin of hip; ; hair follicle; ; glutes; ; germinal epithelium; ; parietal pleura; ; tail of epididymis; ; left ovary;
	Top expressed in
	genital tubercle; ; tail of embryo; ; ventricular zone; ; esophagus; ; yolk sac; ; embryo; ; embryo; ; muscle of thigh; ; lip; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA binding;
Cellular component	preribosome, large subunit precursor; nucleus; nucleolus;
Biological process	rRNA processing; ribosome biogenesis; maturation of LSU-rRNA; maturation of 5.8S rRNA;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10412
	59050
	ENSG00000164346
	ENSMUSG00000060739
	O95478
	Q9CR47
	NM_001271665; NM_014886; NM_001364506
	NM_021552
	NP_001258594; NP_055701; NP_001351435
	NP_067527
	Wikidata
View/Edit Human	View/Edit Mouse

Ribosome biogenesis factor NSA2 homolog is a protein that in humans is encoded by the NSA2 gene (previously TINP1).^[5]^[6]^[7] This protein is involved in the production of the 60S ribosomal subunit.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164346 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060739 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (January 2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703. S2CID 21397515.
↑ Wu X, Ivanova G, Merup M, Jansson M, Stellan B, Grandér D, Zabarovsky E, Gahrton G, Einhorn S (September 1999). "Molecular analysis of the human chromosome 5q13.3 region in patients with hairy cell leukemia and identification of tumor suppressor gene candidates". Genomics. 60 (2): 161–71. doi:10.1006/geno.1999.5911. PMID 10486207.
↑ "Entrez Gene: TINP1 TGF beta-inducible nuclear protein 1".
↑ "O95478 · NSA2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-09-09.

Lebreton A, Saveanu C, Decourty L, Jacquier A, Fromont-Racine M (September 2006). "Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs". The Journal of Biological Chemistry. 281 (37): 27099–108. doi:10.1074/jbc.M602199200. PMID 16861225.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (November 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164346 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060739 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11124703-5] Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (January 2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703. S2CID 21397515.

[pmid10486207-6] Wu X, Ivanova G, Merup M, Jansson M, Stellan B, Grandér D, Zabarovsky E, Gahrton G, Einhorn S (September 1999). "Molecular analysis of the human chromosome 5q13.3 region in patients with hairy cell leukemia and identification of tumor suppressor gene candidates". Genomics. 60 (2): 161–71. doi:10.1006/geno.1999.5911. PMID 10486207.

[entrez-7] "Entrez Gene: TINP1 TGF beta-inducible nuclear protein 1".

[8] "O95478 · NSA2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-09-09.

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NSA2

References

Further reading