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SNX18
Identifiers
Aliases	SNX18, SH3PX2, SH3PXD3B, SNAG1, sorting nexin 18
External IDs	MGI: 2137642; GeneCards: SNX18
Gene location (Human)
Chr.	Chromosome 5 (human)
End	54,546,586 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	113,755,100 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; pancreatic ductal cell; ; skin of arm; ; germinal epithelium; ; amniotic fluid; ; palpebral conjunctiva; ; endothelial cell; ; synovial membrane; ; saphenous vein; ; trabecular bone;
	Top expressed in
	cumulus cell; ; medullary collecting duct; ; ascending aorta; ; external carotid artery; ; renal corpuscle; ; aortic valve; ; tunica media of zone of aorta; ; internal carotid artery; ; secondary oocyte; ; sciatic nerve;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; phosphatidylinositol binding; phosphatidylinositol-4,5-bisphosphate binding; lipid binding;
Cellular component	membrane; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; endosome membrane; extracellular exosome; cytoplasmic vesicle membrane; endomembrane system; clathrin-coated vesicle; cytoplasmic vesicle; endosome;
Biological process	cleavage furrow formation; cell division; endosomal transport; positive regulation of GTPase activity; protein transport; cell cycle; endocytosis; mitotic cytokinesis; mitotic cell cycle; transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	112574
	170625
	ENSG00000178996
	ENSMUSG00000042364
	Q96RF0
	Q91ZR2; Q8C788
	NM_052870; NM_001102575; NM_001145427
	NM_130796
	NP_001096045; NP_001138899; NP_443102
	NP_570614
	Wikidata
View/Edit Human	View/Edit Mouse

Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene.^[5]^[6]^[7]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. The specific function of this protein has not been determined.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000178996 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042364 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Seet LF, Hong W (Sep 2006). "The Phox (PX) domain proteins and membrane traffic". Biochim Biophys Acta. 1761 (8): 878–96. doi:10.1016/j.bbalip.2006.04.011. PMID 16782399.
↑ Thornhill PB, Cohn JB, Drury G, Stanford WL, Bernstein A, Desbarats J (Sep 2007). "A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells". FEBS Lett. 581 (23): 4455–62. doi:10.1016/j.febslet.2007.08.025. PMID 17761170. S2CID 23223511.
1 2 "Entrez Gene: SNAG1 sorting nexin associated golgi protein 1".

Worby CA, Dixon JE (2003). "Sorting out the cellular functions of sorting nexins". Nat. Rev. Mol. Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.
Xu Y, Seet LF, Hanson B, Hong W (2002). "The Phox homology (PX) domain, a new player in phosphoinositide signalling". Biochem. J. 360 (Pt 3): 513–30. doi:10.1042/0264-6021:3600513. PMC 1222253. PMID 11736640.
Ozyildirim AM, Wistow GJ, Gao J, et al. (2005). "The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts". Invest. Ophthalmol. Vis. Sci. 46 (5): 1572–80. CiteSeerX 10.1.1.123.3574. doi:10.1167/iovs.04-1380. PMID 15851553. {{cite journal}}: Cite uses deprecated parameter |citeseerx= (help)
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Schulze WX, Mann M (2004). "A novel proteomic screen for peptide-protein interactions". J. Biol. Chem. 279 (11): 10756–64. doi:10.1074/jbc.M309909200. PMID 14679214.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000178996 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042364 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16782399-5] Seet LF, Hong W (Sep 2006). "The Phox (PX) domain proteins and membrane traffic". Biochim Biophys Acta. 1761 (8): 878–96. doi:10.1016/j.bbalip.2006.04.011. PMID 16782399.

[pmid17761170-6] Thornhill PB, Cohn JB, Drury G, Stanford WL, Bernstein A, Desbarats J (Sep 2007). "A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells". FEBS Lett. 581 (23): 4455–62. doi:10.1016/j.febslet.2007.08.025. PMID 17761170. S2CID 23223511.

[entrez-7] 1 2 "Entrez Gene: SNAG1 sorting nexin associated golgi protein 1".

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[4]

[5]

[6]

[7]

v t e Sorting nexins
SNX-BAR	SNX1 SNX2 SNX4 SNX5 SNX6 SNX7 SNX8 SNX9 SNX18 SNX30 SNX32 SNX33
SNX-PX	SNX3 SNX10 SNX11 SNX12 SNX16 SNX20 SNX21 SNX22 SNX24 SNX29
SNX-Other	SNX13 SNX14 SNX15 SNX17 SNX19 SNX23 SNX25 SNX26 SNX27 SNX28 SNX31
Related articles	PX domain BAR domain Retromer

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References

Further reading