SLC35H1

SLC35H1
Identifiers
Aliases	SLC35H1, BA394O2.1, C20orf5, CGI-15, OVCOV1, solute carrier family 35 member C2, Solute carrier family 35 member H1
External IDs	MGI: 2385166; GeneCards: SLC35H1
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.12 Start 46,345,980 bp End 46,364,458 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 H3|2 85.53 cM Start 165,118,474 bp End 165,129,789 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii right uterine tube granulocyte left lobe of thyroid gland right lobe of thyroid gland stromal cell of endometrium right adrenal cortex left adrenal cortex right ovary minor salivary glands Top expressed in lacrimal gland granulocyte duodenum right kidney dentate gyrus of hippocampal formation granule cell yolk sac jejunum superior frontal gyrus primary visual cortex muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function antiporter activity transmembrane transporter activity Cellular component integral component of membrane cis-Golgi network endoplasmic reticulum-Golgi intermediate compartment membrane membrane endoplasmic reticulum-Golgi intermediate compartment nucleoplasm Golgi apparatus Biological process protein O-linked fucosylation fucosylation negative regulation of gene expression positive regulation of Notch signaling pathway UDP-glucose transmembrane transport Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 51006 228875 Ensembl ENSG00000080189 ENSMUSG00000017664 UniProt Q9NQQ7 Q8VCX2 RefSeq (mRNA) NM_001281457 NM_001281458 NM_001281459 NM_001281460 NM_015945 NM_173073 NM_173179 NM_001252573 NM_001252574 NM_001252575 NM_144893 NM_001363015 NM_001363016 RefSeq (protein) NP_001268386 NP_001268387 NP_001268388 NP_001268389 NP_057029 NP_775096 NP_775271 NP_001239502 NP_001239503 NP_001239504 NP_659142 NP_001349944 NP_001349945 Location (UCSC) Chr 20: 46.35 – 46.36 Mb Chr 2: 165.12 – 165.13 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 35 member H1 is a protein that in humans is encoded by the SLC35H1 gene (previously SLC35C2). This protein was originally thought to act as a GDP-fucose transporter like its homolog SLC35C1, but later research has suggested that this is not the case.

Oxygenation levels play an important role in the regulation of cellular invasiveness which occurs during early implantation when the trophoblast cells invade the uterus as well as during tumour progression and metastasis. This gene, which is regulated by oxygen tension, is induced in hypoxic trophoblast cells and is overexpressed in ovarian cancer. Two protein isoforms are encoded by transcript variants of this gene.

Further reading

• Lash GE, Postovit LM, Matthews NE, et al. (2002). "Oxygen as a regulator of cellular phenotypes in pregnancy and cancer". Can. J. Physiol. Pharmacol. 80 (2): 103–9. doi:10.1139/y02-008. PMID 11934252.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Pires Martins R, Leach RE, Krawetz SA (2001). "Whole-body gene expression by data mining". Genomics. 72 (1): 34–42. doi:10.1006/geno.2000.6437. PMID 11247664.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Leach R, Duniec-Dmuchowski Z, Tanaka T, et al. (2002). "Assignment of OVCOV1 (alias CGI-15) to human chromosome 20 band q13.1→q13.2 by fluorescent in situ hybridization". Cytogenet. Cell Genet. 94 (3–4): 252–3. doi:10.1159/000048828. PMID 11856893. S2CID 33594704.
• Leach RE, Duniec-Dmuchowski ZM, Pesole G, et al. (2003). "Identification, molecular characterization, and tissue expression of OVCOV1". Mamm. Genome. 13 (11): 619–24. doi:10.1007/s00335-002-2185-4. PMID 12461647. S2CID 19423578.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.