// Workers AI · dad joke modeIs 2-iminobutanoate deaminase an enzyme? A-mine to find out.

RIDA
Identifiers
Aliases	RIDA, P14.5, PSP, UK114, HRSP12, Heat-responsive protein 12, reactive intermediate imine deaminase A homolog, hp14.5
External IDs	OMIM: 602487; MGI: 1095401; HomoloGene: 4261; GeneCards: RIDA; OMA:RIDA - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ONI
Enzyme activity
Gene location (Human)
Chr.	Chromosome 8 (human)
End	98,117,171 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	34,495,401 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney tubule; ; caudate nucleus; ; nucleus accumbens; ; putamen; ; amygdala; ; glomerulus; ; human kidney; ; anterior cingulate cortex; ; right adrenal cortex;
	Top expressed in
	right kidney; ; human kidney; ; left lobe of liver; ; proximal tubule; ; yolk sac; ; Epithelium of choroid plexus; ; deep cerebellar nuclei; ; cerebellar cortex; ; vestibular sensory epithelium; ; vestibular membrane of cochlear duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; ion binding; long-chain fatty acid binding; transition metal ion binding; hydrolase activity; RNA binding; deaminase activity; endoribonuclease activity, producing 3'-phosphomonoesters;
Cellular component	cytosol; mitochondrion; extracellular exosome; nucleus; cytoplasm; mitochondrial matrix; peroxisome;
Biological process	kidney development; lung development; G1 to G0 transition; response to lipid; brain development; response to salt; negative regulation of epithelial cell proliferation; RNA phosphodiester bond hydrolysis, endonucleolytic; organonitrogen compound catabolic process; negative regulation of translation; L-threonine catabolic process to glycine;
	Sources:Amigo / QuickGO
Orthologs
	10247
	15473
	ENSG00000132541
	ENSMUSG00000022323
	P52758
	P52760
	NM_005836
	NM_008287
	NP_005827
	NP_032313
	Wikidata
View/Edit Human	View/Edit Mouse

2-iminobutanoate/2-iminopropanoate deaminase is an enzyme that in humans is encoded by the RIDA gene.^[5]^[6]^[7] RIDA is also known as Heat-responsive protein 12 (HRSP12), Ribonuclease UK114, or reactive intermediate imine deaminase A.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000132541 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022323 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Schmiedeknecht G, Kerkhoff C, Orso E, Stohr J, Aslanidis C, Nagy GM, Knuechel R, Schmitz G (Jan 1997). "Isolation and characterization of a 14.5-kDa trichloroacetic-acid-soluble translational inhibitor protein from human monocytes that is upregulated upon cellular differentiation". Eur J Biochem. 242 (2): 339–51. doi:10.1111/j.1432-1033.1996.0339r.x. PMID 8973653.
↑ Schmiedeknecht G, Buchler C, Schmitz G (Jan 1998). "A bidirectional promoter connects the p14.5 gene to the gene for RNase P and RNase MRP protein subunit hPOP1". Biochem Biophys Res Commun. 241 (1): 59–67. doi:10.1006/bbrc.1997.7772. PMID 9405234.
↑ "Entrez Gene: HRSP12 heat-responsive protein 12".

External links

HRSP12 human gene location in the UCSC Genome Browser.
HRSP12 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000132541 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022323 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8973653-5] Schmiedeknecht G, Kerkhoff C, Orso E, Stohr J, Aslanidis C, Nagy GM, Knuechel R, Schmitz G (Jan 1997). "Isolation and characterization of a 14.5-kDa trichloroacetic-acid-soluble translational inhibitor protein from human monocytes that is upregulated upon cellular differentiation". Eur J Biochem. 242 (2): 339–51. doi:10.1111/j.1432-1033.1996.0339r.x. PMID 8973653.

[pmid9405234-6] Schmiedeknecht G, Buchler C, Schmitz G (Jan 1998). "A bidirectional promoter connects the p14.5 gene to the gene for RNase P and RNase MRP protein subunit hPOP1". Biochem Biophys Res Commun. 241 (1): 59–67. doi:10.1006/bbrc.1997.7772. PMID 9405234.

[entrez-7] "Entrez Gene: HRSP12 heat-responsive protein 12".

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// Workers AI · dad joke modeIs 2-iminobutanoate deaminase an enzyme? A-mine to find out.

References

Further reading

External links