RAS p21 protein activator 2

RASA2
Identifiers
Aliases	RASA2, GAP1M, RAS p21 protein activator 2
External IDs	OMIM: 601589; MGI: 2149960; HomoloGene: 4745; GeneCards: RASA2; OMA:RASA2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q23 Start 141,487,027 bp End 141,615,344 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 E3.3 Start 96,539,300 bp End 96,631,617 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx superficial temporal artery trabecular bone nipple tibia skin of hip visceral pleura Brodmann area 23 parietal pleura Achilles tendon Top expressed in Rostral migratory stream secondary oocyte primary oocyte zygote median eminence granulocyte primary motor cortex lymph node mesenteric lymph nodes olfactory bulb More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding GTPase activator activity phospholipid binding Cellular component cytoplasm cytosol intrinsic component of the cytoplasmic side of the plasma membrane perinuclear region of cytoplasm Biological process intracellular signal transduction regulation of GTPase activity MAPK cascade positive regulation of GTPase activity signal transduction negative regulation of Ras protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5922 114713 Ensembl ENSG00000155903 ENSMUSG00000032413 UniProt Q15283 P58069 RefSeq (mRNA) NM_001303245 NM_001303246 NM_006506 NM_053268 RefSeq (protein) NP_001290174 NP_001290175 NP_006497 NP_444498 Location (UCSC) Chr 3: 141.49 – 141.62 Mb Chr 9: 96.54 – 96.63 Mb PubMed search
Wikidata
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RAS p21 protein activator 2 is a protein that in humans is encoded by the RASA2 gene.

Function

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]. It has been shown that RASA2 promotes a shift from noncanonical to canonical TGF-β signaling through SMAD3 in B cells.

Further reading

• Lockyer PJ, Wennström S, Kupzig S, Venkateswarlu K, Downward J, Cullen PJ (March 1999). "Identification of the ras GTPase-activating protein GAP1(m) as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo". Curr. Biol. 9 (5): 265–8. doi:10.1016/s0960-9822(99)80116-x. PMID 10074452. S2CID 8695013.
• Mamand, Sami; Liu, Heather; Kashem, Mohammad; Martin, Alberto (25 October 2024). "Suppression of Class Switch Recombination to IgA by RASA2 and RASA3 through Inhibition of TGF-β Signaling". The Journal of Immunology. 213 (9): 1739–1745. doi:10.4049/jimmunol.2400353. PMID 39451029.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.