// Workers AI · dad joke modeWhat did Phospholipase A2 group IVD say? "I've got a lipase to settle.

PLA2G4D
Identifiers
Aliases	PLA2G4D, cPLA2delta, phospholipase A2 group IVD
External IDs	OMIM: 612864; MGI: 1925640; HomoloGene: 52252; GeneCards: PLA2G4D; OMA:PLA2G4D - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5IXC, 5IZR, 5IZ5
Enzyme activity
Gene location (Human)
Chr.	Chromosome 15 (human)
End	42,094,562 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	120,119,678 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; skin of leg; ; gonad; ; testicle; ; vagina; ; pituitary gland; ; anterior pituitary; ; prostate; ; ectocervix; ; endometrium;
	Top expressed in
	esophagus; ; primary oocyte; ; placenta; ; secondary oocyte; ; decidua; ; spermatid; ; embryo; ; lumbar subsegment of spinal cord; ; zygote; ; seminiferous tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	phospholipase activity; metal ion binding; hydrolase activity; phospholipase A1 activity; lysophospholipase activity; phospholipase A2 activity; calcium-dependent phospholipase A2 activity; calcium ion binding; calcium-dependent phospholipid binding;
Cellular component	cytoplasm; cytosol; membrane;
Biological process	phosphatidic acid biosynthetic process; phosphatidylserine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; lipid metabolism; phosphatidylinositol acyl-chain remodeling; lipid catabolic process; phosphatidylglycerol acyl-chain remodeling; phospholipid catabolic process; phospholipid metabolic process; metabolism; phosphatidylcholine acyl-chain remodeling; glycerophospholipid catabolic process; fatty acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	283748
	78390
	ENSG00000159337
	ENSMUSG00000070719
	Q86XP0
	Q50L43
	NM_178034
	NM_001024137
	NP_828848
	NP_001019308
	Wikidata
View/Edit Human	View/Edit Mouse

Phospholipase A2 group IVD is a protein that in humans is encoded by the PLA2G4D gene.^[5]

Function

The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000159337 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070719 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Phospholipase A2 group IVD". Retrieved 2017-09-13.
↑ Chiba H, Michibata H, Wakimoto K, Seishima M, Kawasaki S, Okubo K, et al. (March 2004). "Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin". The Journal of Biological Chemistry. 279 (13): 12890–12897. doi:10.1074/jbc.M305801200. PMID 14709560.

Tao R, Yu Y, Zhang X, Shi J, Guo Y, Wang C, et al. (2005). "A family based study of the genetic association between the PLA2G4D gene and schizophrenia". Prostaglandins, Leukotrienes, and Essential Fatty Acids. 73 (6): 419–422. doi:10.1016/j.plefa.2005.08.008. PMID 16213696.
Yu Q, Shi JP, Kou CG, Meng XF, Yu YQ (2008). "[Study on the genetic association between the polymorphism of cytosolic phospholipase A2 family genes and schizophrenia]". Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi (in Chinese). 29 (2): 173–176. PMID 18686860.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". American Journal of Human Genetics. 85 (5): 628–642. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–2253. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
Parry M, Rose-Zerilli MJ, Gibson J, Ennis S, Walewska R, Forster J, et al. (2013). "Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma". PLOS ONE. 8 (12) e83244. Bibcode:2013PLoSO...883244P. doi:10.1371/journal.pone.0083244. PMC 3862727. PMID 24349473.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000159337 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070719 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Phospholipase A2 group IVD". Retrieved 2017-09-13.

[6] Chiba H, Michibata H, Wakimoto K, Seishima M, Kawasaki S, Okubo K, et al. (March 2004). "Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin". The Journal of Biological Chemistry. 279 (13): 12890–12897. doi:10.1074/jbc.M305801200. PMID 14709560.

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// Workers AI · dad joke modeWhat did Phospholipase A2 group IVD say? "I've got a lipase to settle.

Function

References

Further reading