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NKD2
Identifiers
Aliases	NKD2, Naked2, Naked cuticle 2, naked cuticle homolog 2, WNT signaling pathway inhibitor, NKD inhibitor of WNT signaling pathway 2
External IDs	OMIM: 607852; MGI: 1919543; HomoloGene: 12459; GeneCards: NKD2; OMA:NKD2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	1,038,943 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	73,995,750 bp
RNA expression pattern
	Top expressed in
	upper lobe of left lung; ; right lung; ; spleen; ; skin of abdomen; ; skin of leg; ; left adrenal cortex; ; right testis; ; left testis; ; right adrenal gland; ; placenta;
	Top expressed in
	tail of embryo; ; genital tubercle; ; hand; ; hair follicle; ; foot; ; maxillary prominence; ; paraxial mesoderm; ; mandibular prominence; ; iris; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; growth factor binding; metal ion binding; protein binding; ubiquitin protein ligase binding; myosin heavy chain binding; ATPase binding;
Cellular component	cytoplasm; lateral plasma membrane; membrane; basolateral plasma membrane; cytoplasmic vesicle; cell periphery; plasma membrane; exocytic vesicle;
Biological process	Wnt signaling pathway; positive regulation of protein processing; Golgi vesicle fusion to target membrane; negative regulation of canonical Wnt signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; exocytosis; protein localization to plasma membrane; positive regulation of protein localization to plasma membrane; negative regulation of Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	85409
	72293
	ENSG00000145506; ENSG00000276920
	ENSMUSG00000021567
	Q969F2
	Q8VE28
	NM_001271082; NM_033120
	NM_028186; NM_001347535
	NP_001258011; NP_149111
	NP_001334464; NP_082462
	Wikidata
View/Edit Human	View/Edit Mouse

Naked cuticle homolog 2 (Naked-2) is a protein which in humans is encoded by the gene NKD2. Naked-2 is one of the Naked cuticle (Nkd) family of proteins that regulate the Wnt signaling pathway.^[5]^[6] Both naked-1 and naked-2 proteins can bind to Dishevelled proteins (DVL1, DVL2, DVL3), but only naked-2 can bind to the EGF-ligand family member TGF alpha and regulate its polarized secretion in cultured epithelial cells.^[7]

Sources

1 2 3 ENSG00000276920 GRCh38: Ensembl release 89: ENSG00000145506, ENSG00000276920 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021567 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wharton, KA Jr; Zimmermann, G; Rousset, R; Scott, MP (Jun 2001). "Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling". Dev. Biol. 234 (1): 93–106. doi:10.1006/dbio.2001.0238. PMID 11356022. S2CID 18903944.
↑ Katoh, M (Nov 2001). "Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2". Int J Oncol. 19 (5): 963–9. doi:10.3892/ijo.19.5.963. PMID 11604995.
↑ Li, C; Franklin, JL; Graves-Deal, R; Jerome, WG; Cao, Z; Coffey, RJ (Apr 2004). "Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells". Proc Natl Acad Sci U S A. 101 (15): 5571–6. Bibcode:2004PNAS..101.5571L. doi:10.1073/pnas.0401294101. PMC 397424. PMID 15064403.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000276920 GRCh38: Ensembl release 89: ENSG00000145506, ENSG00000276920 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021567 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Wharton, KA Jr; Zimmermann, G; Rousset, R; Scott, MP (Jun 2001). "Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling". Dev. Biol. 234 (1): 93–106. doi:10.1006/dbio.2001.0238. PMID 11356022. S2CID 18903944.

[6] Katoh, M (Nov 2001). "Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2". Int J Oncol. 19 (5): 963–9. doi:10.3892/ijo.19.5.963. PMID 11604995.

[7] Li, C; Franklin, JL; Graves-Deal, R; Jerome, WG; Cao, Z; Coffey, RJ (Apr 2004). "Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells". Proc Natl Acad Sci U S A. 101 (15): 5571–6. Bibcode:2004PNAS..101.5571L. doi:10.1073/pnas.0401294101. PMC 397424. PMID 15064403.

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// Workers AI · dad joke modeIs Naked cuticle 2 a good nail polish name? It's a cut above.

Sources