Naked cuticle 1

NKD1
Identifiers
Aliases	NKD1, Naked1, Naked cuticle 1, naked cuticle homolog 1, WNT signaling pathway inhibitor, NKD inhibitor of WNT signaling pathway 1
External IDs	OMIM: 607851; MGI: 2135954; HomoloGene: 12343; GeneCards: NKD1; OMA:NKD1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	50,649,249 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	89,321,512 bp
RNA expression pattern
	Top expressed in
	right lung; ; saphenous vein; ; lateral nuclear group of thalamus; ; popliteal artery; ; tibial arteries; ; endothelial cell; ; sural nerve; ; lower lobe of lung; ; Descending thoracic aorta; ; ascending aorta;
	Top expressed in
	zygote; ; secondary oocyte; ; gastrula; ; tail of embryo; ; primary oocyte; ; left lung lobe; ; Rostral migratory stream; ; seminal vesicula; ; lumbar subsegment of spinal cord; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; PDZ domain binding; protein binding; metal ion binding;
Cellular component	cytoplasm; plasma membrane; protein phosphatase type 2A complex; membrane;
Biological process	negative regulation of Wnt signaling pathway; positive regulation of Wnt signaling pathway, planar cell polarity pathway; positive regulation of non-canonical Wnt signaling pathway via JNK cascade; somatic muscle development; eye photoreceptor cell differentiation; Wnt signaling pathway; positive regulation of protein catabolic process; negative regulation of canonical Wnt signaling pathway; regulation of cell migration involved in somitogenic axis elongation; negative regulation of convergent extension involved in axis elongation;
	Sources:Amigo / QuickGO
Orthologs
	85407
	93960
	ENSG00000140807
	ENSMUSG00000031661
	Q969G9
	Q99MH6
	NM_033119
	NM_001163660; NM_027280
	NP_149110
	NP_001157132; NP_081556
	Wikidata
View/Edit Human	View/Edit Mouse

Naked cuticle homolog 1 (Naked-1) is a protein which in humans is encoded by the gene NKD1. Naked-1 is a member of the Naked cuticle (Nkd) family of proteins that regulate the Wnt signaling pathway.^[5]^[6]^[7] Insects typically have a single Nkd gene, whereas there are two Nkd genes, Nkd1 and Nkd2, in most vertebrates studied to date (zebrafish appear to have additional homologous genes such as Nkd3).^[8]^[9] Nkd1 binds to the Dishevelled (Dvl) family of proteins (DVL1, DVL2, DVL3). Specific truncating NKD1 mutations identified in DNA mismatch repair deficient colon cancer that disrupt Nkd1/Dvl binding implicate these mutations as a cause of increased Wnt signaling in a subset of human colon cancers, the majority of which have increased Wnt signaling due to mutations the adenomatous polyposis coli (APC), AXIN2, or rarely the beta-catenin genes.^[10]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000140807 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031661 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wharton KA Jr, Zimmermann G, Rousset R, Scott MP. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. Dev Biol. 2001 Jun 1;234(1):93-106. PMID 11356022
↑ Yan D, Wallingford JB, Sun TQ, Nelson AM, Sakanaka C, Reinhard C, Harland RM, Fantl WJ, Williams LT. Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3802-7. PMID 11274398
↑ Katoh M. Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2. Int J Oncol. 2001 Nov;19(5):963-9. PMID 11604995
↑ Van Raay TJ, Coffey RJ, Solnica-Krezel L. Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling. Dev Biol. 2007 Sep 15;309(2):151-68. Epub 2007 Apr 21. PMID 17689523
↑ Schneider I, Schneider PN, Derry SW, Lin S, Barton LJ, Westfall T, Slusarski DC. Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning. Dev Biol. 2010 Dec 1;348(1):22-33. Epub 2010 Sep 19. PMID 20858476
↑ Guo J, Cagatay T, Zhou G, Chan CC, Blythe S, Suyama K, Zheng L, Pan K, Qian C, Hamelin R, Thibodeau SN, Klein PS, Wharton KA, Liu W. Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. PLoS One. 2009 Nov 24;4(11):e7982.PMID 19956716

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000140807 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031661 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Wharton KA Jr, Zimmermann G, Rousset R, Scott MP. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. Dev Biol. 2001 Jun 1;234(1):93-106. PMID 11356022

[6] Yan D, Wallingford JB, Sun TQ, Nelson AM, Sakanaka C, Reinhard C, Harland RM, Fantl WJ, Williams LT. Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3802-7. PMID 11274398

[7] Katoh M. Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2. Int J Oncol. 2001 Nov;19(5):963-9. PMID 11604995

[8] Van Raay TJ, Coffey RJ, Solnica-Krezel L. Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling. Dev Biol. 2007 Sep 15;309(2):151-68. Epub 2007 Apr 21. PMID 17689523

[9] Schneider I, Schneider PN, Derry SW, Lin S, Barton LJ, Westfall T, Slusarski DC. Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning. Dev Biol. 2010 Dec 1;348(1):22-33. Epub 2010 Sep 19. PMID 20858476

[10] Guo J, Cagatay T, Zhou G, Chan CC, Blythe S, Suyama K, Zheng L, Pan K, Qian C, Hamelin R, Thibodeau SN, Klein PS, Wharton KA, Liu W. Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. PLoS One. 2009 Nov 24;4(11):e7982.PMID 19956716

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

This page was redesigned at the edge.

A page that knows where it met you.

Naked cuticle 1

References