SLC61A1

SLC61A1
Identifiers
Aliases	SLC61A1, hsMOT2, major facilitator superfamily domain containing 5, MFSD5, Solute carrier family 61 member 1
External IDs	MGI: 2145901; GeneCards: SLC61A1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,254,406 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,190,189 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; mucosa of transverse colon; ; right adrenal cortex; ; granulocyte; ; left adrenal gland; ; left adrenal cortex; ; gums; ; gingival epithelium; ; apex of heart;
	Top expressed in
	lip; ; stroma of bone marrow; ; transitional epithelium of urinary bladder; ; esophagus; ; right kidney; ; skin of external ear; ; calvaria; ; yolk sac; ; choroid plexus of fourth ventricle; ; granulocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; molybdate ion transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	molybdate ion transport; ion transport; transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	84975
	106073
	ENSG00000182544
	ENSMUSG00000045665
	Q6N075
	Q921Y4
	NM_001170790; NM_032889
	NM_134100
	NP_001164261; NP_116278
	NP_598861
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 61 member 1 is a protein that in humans is encoded by the SLC61A1 gene (previously MFSD4).^[5] This protein is responsible for molybdenum uptake instead of the cell.^[5] It has previously been described as an atypical SLC, and it is expressed in neuronal plasma membrane.^[6] It is a plausible Solute carrier transporter.^[7] It transports molybdate anions,^[8] and it interacts with GLP-1R.^[9] In humans, it is encoded by the gene SLC61A1.^[10]

SLC61A1/MFSD5 belongs to AMTF6.^[11]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000182544 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045665 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Solute carrier family 61 member 1". uniprot.org. UniProt consortium. Retrieved 2026-09-13.
↑ Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6) e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
↑ Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
↑ Tejada-Jiménez M, Galván A, Fernández E (April 2011). "Algae and humans share a molybdate transporter". Proceedings of the National Academy of Sciences of the United States of America. 108 (16): 6420–6425. Bibcode:2011PNAS..108.6420T. doi:10.1073/pnas.1100700108. PMC 3080982. PMID 21464289.
↑ Huang X, Dai FF, Gaisano G, Giglou K, Han J, Zhang M, et al. (September 2013). "The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity". Molecular Endocrinology. 27 (9): 1550–1563. doi:10.1210/me.2013-1047. PMC 5415235. PMID 23864651.
↑ "genecards.org".
↑ Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9) 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000182544 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045665 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-5] 1 2 "Solute carrier family 61 member 1". uniprot.org. UniProt consortium. Retrieved 2026-09-13.

[6] Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6) e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.

[7] Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.

[8] Tejada-Jiménez M, Galván A, Fernández E (April 2011). "Algae and humans share a molybdate transporter". Proceedings of the National Academy of Sciences of the United States of America. 108 (16): 6420–6425. Bibcode:2011PNAS..108.6420T. doi:10.1073/pnas.1100700108. PMC 3080982. PMID 21464289.

[9] Huang X, Dai FF, Gaisano G, Giglou K, Han J, Zhang M, et al. (September 2013). "The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity". Molecular Endocrinology. 27 (9): 1550–1563. doi:10.1210/me.2013-1047. PMC 5415235. PMID 23864651.

[10] "genecards.org".

[11] Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9) 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.

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SLC61A1

References