// Workers AI · dad joke modeWhy did Myosin regulatory light chain 11 go to therapy? It had a lot of chain reactions.

MYL11
Identifiers
Aliases	MYL11, MYLPF, myosin light chain 11, HUMMLC2B, MLC2B, myosin light chain, phosphorylatable, fast skeletal muscle, MRLC2, DA1C
External IDs	OMIM: 617378; MGI: 97273; GeneCards: MYL11
Gene location (Human) Chr. Chromosome 16 (human) Band 16p11.2 Start 30,370,934 bp End 30,377,991 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F3 Start 126,808,062 bp End 126,813,470 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii Skeletal muscle tissue of biceps brachii Skeletal muscle tissue of rectus abdominis triceps brachii muscle muscle of thigh gastrocnemius muscle vastus lateralis muscle glutes thoracic diaphragm body of tongue Top expressed in temporal muscle sternocleidomastoid muscle triceps brachii muscle digastric muscle medial head of gastrocnemius muscle muscle of thigh vastus lateralis muscle body of femur intercostal muscle ankle More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding structural constituent of muscle metal ion binding Cellular component lysosomal membrane cytosol muscle myosin complex myosin complex Biological process muscle contraction skeletal muscle tissue development immune response Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 29895 17907 Ensembl ENSG00000180209 ENSMUSG00000030672 UniProt Q96A32 P97457 RefSeq (mRNA) NM_013292 NM_001324458 NM_001324459 NM_016754 NM_001347655 RefSeq (protein) NP_001311387 NP_001311388 NP_037424 NP_001334584 NP_058034 Location (UCSC) Chr 16: 30.37 – 30.38 Mb Chr 7: 126.81 – 126.81 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Myosin regulatory light chain 11 is a protein that in humans is encoded by the MYL11 gene (previously MYLPF). Based on research on an ortholog in zebrafish, this protein is predicted to be a regulatory subunit for myosin which is involved in early muscle development, and to also be involved in muscle contraction.

Further reading

• Nudel U, Calvo JM, Shani M, Levy Z (Sep 1984). "The nucleotide sequence of a rat myosin light chain 2 gene". Nucleic Acids Research. 12 (18): 7175–86. doi:10.1093/nar/12.18.7175. PMC 320149. PMID 6091059.
• Garfinkel LI, Periasamy M, Nadal-Ginard B (Sep 1982). "Cloning and characterization of cDNA sequences corresponding to myosin light chains 1, 2, and 3, troponin-C, troponin-T, alpha-tropomyosin, and alpha-actin". The Journal of Biological Chemistry. 257 (18): 11078–86. doi:10.1016/S0021-9258(18)33935-8. PMID 6179945.
• Sachdev S, Raychowdhury MK, Sarkar S (Oct 2003). "Human fast skeletal myosin light chain 2 cDNA: isolation, tissue specific expression of the single copy gene, comparative sequence analysis of isoforms and evolutionary relationships". DNA Sequence. 14 (5): 339–50. doi:10.1080/1042517031000154952. PMID 14756420. S2CID 7284166.
• Amoresano A, Di Costanzo A, Leo G, Di Cunto F, La Mantia G, Guerrini L, Calabrò V (Apr 2010). "Identification of DeltaNp63alpha protein interactions by mass spectrometry". Journal of Proteome Research. 9 (4): 2042–8. doi:10.1021/pr9011156. PMID 20085233.