Theobromine synthase
(Redirected from MXMT)
| Theobromine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.159 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Theobromine synthase (EC 2.1.1.159) is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which the 7-methylxanthine is converted to theobromine. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from coffee plants.[1][2]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:7-methylxanthine N3-methyltransferase. Other names in common use include monomethylxanthine methyltransferase, MXMT, CTS1, CTS2, and S-adenosyl-L-methionine:7-methylxanthine 3-N-methyltransferase.[3] The reaction is part of the biosynthesis pathway to caffeine.[4]
References
[edit]- ↑ Ogawa M, Herai Y, Koizumi N, Kusano T, Sano H (2001). "7-Methylxanthine methyltransferase of coffee plants. Gene isolation and enzymatic properties". J. Biol. Chem. 276 (11): 8213–8. doi:10.1074/jbc.M009480200. PMID 11108716.
- ↑ Uefuji H, Ogita S, Yamaguchi Y, Koizumi N, Sano H (2003). "Molecular cloning and functional characterization of three distinct N-methyltransferases involved in the caffeine biosynthetic pathway in coffee plants". Plant Physiol. 132 (1): 372–80. doi:10.1104/pp.102.019679. PMC 166982. PMID 12746542.
- ↑ Enzyme 2.1.1.159 at KEGG Pathway Database.
- ↑ Yoneyama N, Morimoto H, Ye CX, Ashihara H, Mizuno K, Kato M (2006). "Substrate specificity of N-methyltransferase involved in purine alkaloids synthesis is dependent upon one amino acid residue of the enzyme". Mol. Genet. Genomics. 275 (2): 125–35. doi:10.1007/s00438-005-0070-z. PMID 16333668. S2CID 8338121.
