// Workers AI · dad joke modeWhat did Multiple C2 domains say? I'm bonded to you.

MCTP2
Identifiers
Aliases	MCTP2, multiple C2 and transmembrane domain containing 2
External IDs	OMIM: 616297; MGI: 2685335; HomoloGene: 69254; GeneCards: MCTP2; OMA:MCTP2 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EP6
Gene location (Human) Chr. Chromosome 15 (human) Band 15q26.2 Start 94,231,538 bp End 94,483,952 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 D1 Start 71,727,578 bp End 71,956,356 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium secondary oocyte buccal mucosa cell blood visceral pleura parietal pleura spleen bone marrow bone marrow cell mucosa of sigmoid colon Top expressed in secondary oocyte zygote primary oocyte granulocyte lumbar spinal ganglion lacrimal gland Paneth cell left lobe of liver submandibular gland blood More reference expression data BioGPS n/a
Gene ontology Molecular function calcium-dependent phospholipid binding calcium ion binding Cellular component integral component of membrane endoplasmic reticulum membrane nucleoplasm cytosol synaptic vesicle membrane Biological process multicellular organism development calcium-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55784 244049 Ensembl ENSG00000140563 ENSMUSG00000032776 UniProt Q6DN12 Q5RJH2 RefSeq (mRNA) NM_001159643 NM_001159644 NM_018349 NM_001024703 RefSeq (protein) NP_001153115 NP_001153116 NP_060819 NP_001019874 Location (UCSC) Chr 15: 94.23 – 94.48 Mb Chr 7: 71.73 – 71.96 Mb PubMed search
Wikidata
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Multiple C2 domains, transmembrane 2 is a protein that in humans is encoded by the MCTP2 gene.

Further reading

• Shin OH, Han W, Wang Y, Südhof TC (2005). "Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties". J. Biol. Chem. 280 (2): 1641–51. doi:10.1074/jbc.M407305200. PMID 15528213.
• Verma R, Holmans P, Knowles JA, Grover D, Evgrafov OV, Crowe RR, Scheftner WA, Weissman MM, DePaulo JR, Potash JB, Levinson DF (2008). "Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3". Biol. Psychiatry. 63 (12): 1185–9. doi:10.1016/j.biopsych.2008.02.005. PMC 2435230. PMID 18367154.
• Djurovic S, Le Hellard S, Kähler AK, Jönsson EG, Agartz I, Steen VM, Hall H, Wang AG, Rasmussen HB, Melle I, Werge T, Andreassen OA (2009). "Association of MCTP2 gene variants with schizophrenia in three independent samples of Scandinavian origin (SCOPE)". Psychiatry Res. 168 (3): 256–8. doi:10.1016/j.psychres.2008.08.007. PMID 19223264. S2CID 31236485.
• Djurovic S, Le Hellard S, Kähler AK, Jönsson EG, Agartz I, Steen VM, Hall H, Wang AG, Rasmussen HB, Melle I, Werge T, Andreassen OA (2009). "Association of MCTP2 gene variants with schizophrenia in three independent samples of Scandinavian origin (SCOPE)". Psychiatry Res. 168 (3): 256–8. doi:10.1016/j.psychres.2008.08.007. PMID 19223264. S2CID 31236485.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.