MDA-MB-468
MDA-MB-468 is a cell line that was isolated from a 51-year-old female human in 1977, and is commonly used in breast cancer research. MDA-MB-468 cells were extracted from a pleural effusion of mammary gland and breast tissues, and have proven useful for the study of metastasis, migration, and breast cancer proliferation[1][2].
The cell line was isolated in 1977 by Relda Cailleau, et al., from a pleural effusion of a 51-year-old Black female patient with metastatic adenocarcinoma of the breast. Although the tissue donor was heterozygous for G6PD alleles, the cell line consistently showed only the G6PD A phenotype. MDA-MB-468 cells have a modal chromosome number of 64, though the actual number can vary from 60 to 67 in different cells.[citation needed]
MDA-MB-468 has been used to test chemical breast cancer treatments.[3]
See also
[edit]References
[edit]- ↑ Quinsgaard, Ellen Marie Botne; Korsnes, Mónica Suárez; Korsnes, Reinert; Moestue, Siver Andreas (2024-04-01). "Single-cell tracking as a tool for studying EMT-phenotypes". Experimental Cell Research. 437 (1): 113993. doi:10.1016/j.yexcr.2024.113993. ISSN 0014-4827.
{{cite journal}}: CS1 maint: article number as page number (link) - ↑ Korsnes, Mónica Suárez; Quinsgaard, Ellen Marie Botne; Moestue, Siver Andreas; Korsnes, Reinert (2026-09-14). "Lineage-resolved lifetime modelling reveals potential quiescence and synchronization among MDA-MB-468 breast cancer cells". Frontiers in Cell and Developmental Biology. 14. Frontiers. doi:10.3389/fcell.2026.1911886. ISSN 2296-634X. PMC 13624361. PMID 42818886.
- ↑ Wang, WL; Porter, W; et al. (May 1997). "Mechanism of inhibition of MDA-MB-468 breast cancer cell growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin". Carcinogenesis. 18 (5): 925–933. doi:10.1093/carcin/18.5.925. PMID 9163677.
External links
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