// Workers AI · dad joke modeWhat did CARMIL1 say to its friend? "You can mil1 me for advice.

CARMIL1
Identifiers
Aliases	CARMIL1, CARMIL, CARMIL1a, LRRC16, dJ501N12.1, dJ501N12.5, LRRC16A, leucine rich repeat containing 16A, capping protein regulator and myosin 1 linker 1
External IDs	OMIM: 609593; MGI: 1915982; HomoloGene: 9757; GeneCards: CARMIL1; OMA:CARMIL1 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LK2, 3LK3
Gene location (Human)
Chr.	Chromosome 6 (human)
End	25,620,530 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	24,464,778 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; Achilles tendon; ; mucosa of transverse colon; ; left coronary artery; ; right hemisphere of cerebellum; ; thoracic aorta; ; Descending thoracic aorta; ; ascending aorta; ; testicle;
	Top expressed in
	zygote; ; secondary oocyte; ; molar; ; saccule; ; primary oocyte; ; otic vesicle; ; spermatid; ; vestibular sensory epithelium; ; otic placode; ; medullary collecting duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-containing complex binding; protein binding;
Cellular component	filamentous actin; cell projection; membrane; plasma membrane; macropinosome; cell leading edge; extracellular exosome; cytoskeleton; nucleus; lamellipodium; cytoplasm; cytosol; nuclear speck;
Biological process	barbed-end actin filament uncapping; positive regulation of lamellipodium organization; negative regulation of barbed-end actin filament capping; positive regulation of actin filament polymerization; ruffle organization; actin filament organization; positive regulation of cell migration; actin filament network formation; blood coagulation; positive regulation of substrate adhesion-dependent cell spreading; macropinocytosis; urate metabolic process; cell migration; positive regulation of stress fiber assembly; lamellipodium assembly;
	Sources:Amigo / QuickGO
Orthologs
	55604
	68732
	ENSG00000079691
	ENSMUSG00000021338
	Q5VZK9
	Q6EDY6
	NM_001173977; NM_017640
	NM_026825; NM_177807; NM_001311122; NM_001384122
	NP_001167448; NP_060110
	NP_001298051; NP_081101; NP_001371051
	Wikidata
View/Edit Human	View/Edit Mouse

CARMIL1 is a protein that in humans is encoded by the CARMIL1 gene.^[5] The gene is also known as LRRC16, LRRC16A, CARMIL, or CARMIL1a.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000079691 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021338 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "capping protein regulator and myosin 1 linker 1". Retrieved 2020-11-09.

Yang C, Pring M, Wear MA, Huang M, Cooper JA, Svitkina TM, et al. (August 2005). "Mammalian CARMIL inhibits actin filament capping by capping protein". Developmental Cell. 9 (2): 209–221. doi:10.1016/j.devcel.2005.06.008. PMC 2628720. PMID 16054028.
Liang Y, Niederstrasser H, Edwards M, Jackson CE, Cooper JA (December 2009). "Distinct roles for CARMIL isoforms in cell migration". Molecular Biology of the Cell. 20 (24): 5290–5305. doi:10.1091/mbc.E08-10-1071. PMC 2793302. PMID 19846667.
Gunjaca G, Boban M, Pehlić M, Zemunik T, Budimir D, Kolcić I, et al. (February 2010). "Predictive value of 8 genetic loci for serum uric acid concentration". Croatian Medical Journal. 51 (1): 23–31. doi:10.3325/cmj.2010.51.23. PMC 2829178. PMID 20162742.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000079691 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021338 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "capping protein regulator and myosin 1 linker 1". Retrieved 2020-11-09.

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// Workers AI · dad joke modeWhat did CARMIL1 say to its friend? "You can mil1 me for advice.

References

Further reading