// Workers AI · dad joke modeWhat did Layilin say when tired? "I'm laid out.

LAYN
Identifiers
Aliases	LAYN, Layilin
External IDs	MGI: 2685357; HomoloGene: 18716; GeneCards: LAYN; OMA:LAYN - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	111,561,745 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	50,988,394 bp
RNA expression pattern
	Top expressed in
	decidua; ; stromal cell of endometrium; ; amniotic fluid; ; ascending aorta; ; pancreatic epithelial cell; ; Descending thoracic aorta; ; muscle layer of sigmoid colon; ; smooth muscle tissue; ; urethra; ; left ovary;
	Top expressed in
	aortic valve; ; ascending aorta; ; endothelial cell of lymphatic vessel; ; embryo; ; embryo; ; facial motor nucleus; ; lens; ; blood; ; supraoptic nucleus; ; cumulus cell;
	More reference expression data
	n/a
Orthologs
	143903
	244864
	ENSG00000204381
	ENSMUSG00000060594
	Q6UX15
	Q8C351
	NM_001258390; NM_001258391; NM_178834; NM_001318799
	NM_001033534
	NP_001245319; NP_001245320; NP_001305728; NP_849156
	NP_001028706
	Wikidata
View/Edit Human	View/Edit Mouse

Layilin is a protein that in humans is encoded by the LAYN gene.^[5]

Medical Relevance

A study has shown that Layilin is upregulated in tumor infiltrating CD8+ Cytotoxic T cells of patients with liver cancer.^[6]

1 2 3 GRCh38: Ensembl release 89: ENSG00000204381 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060594 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Layilin".
↑ Zheng C, Zheng L, Yoo JK, Guo H, Zhang Y, Guo X, Kang B, Hu R, Huang JY, Zhang Q, Liu Z, Dong M, Hu X, Ouyang W, Peng J, Zhang Z (2017). "Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing". Cell. 169 (7): 1342–1356.e16. doi:10.1016/j.cell.2017.05.035. PMID 28622514.

Bono P, Rubin K, Higgins JM, Hynes RO (2001). "Layilin, a novel integral membrane protein, is a hyaluronan receptor". Mol. Biol. Cell. 12 (4): 891–900. doi:10.1091/mbc.12.4.891. PMC 32274. PMID 11294894.
Borowsky ML, Hynes RO (1998). "Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles". J. Cell Biol. 143 (2): 429–42. doi:10.1083/jcb.143.2.429. PMC 2132847. PMID 9786953.
Forteza RM, Casalino-Matsuda SM, Falcon NS, Valencia Gattas M, Monzon ME (2012). "Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin". J. Biol. Chem. 287 (50): 42288–98. doi:10.1074/jbc.M112.387795. PMC 3516772. PMID 23048036.
Bono P, Cordero E, Johnson K, Borowsky M, Ramesh V, Jacks T, Hynes RO (2005). "Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin". Exp. Cell Res. 308 (1): 177–87. doi:10.1016/j.yexcr.2005.04.017. PMID 15913605.

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