Ignacio Tinoco Jr.
Ignacio Tinoco Jr. | |
|---|---|
| Born | November 22, 1930 |
| Died | November 15, 2016 (aged 85) |
| Education | University of New Mexico, University of Wisconsin, Madison, Yale University |
| Known for | Pioneering work on RNA folding and the secondary structures of ribonucleic acid |
| Scientific career | |
| Fields | Chemistry |
| Institutions | University of California, Berkeley, Lawrence Berkeley National Laboratory |
| John D. Ferry | |
Other academic advisors | John G. Kirkwood |
Doctoral students | Carlos Bustamante, Charles Cantor |
Other notable students | Frances Arnold |
Ignacio "Nacho" Tinoco Jr. (November 22, 1930 – November 15, 2016) was a Professor of Chemistry at the University of California, Berkeley from 1956 to 2016.[1][2][3]
Ignacio Tinoco received a bachelor's degree from the University of New Mexico in 1951, and a Ph.D. in physical chemistry at the University of Wisconsin, Madison in 1954.[4] He was a postdoctoral fellow with John G. Kirkwood at Yale University from 1954 to 1956.[4] He joined the University of California, Berkeley as a faculty member in 1956, where he was professor in the graduate school and a faculty senior scientist, physical biosciences division, Lawrence Berkeley National Laboratory. He was chairman of the chemistry department (1979–82).[5]
Tinoco, together with Carlos Bustamante (biophysicist) and Marcos F. Maestre, developed the theory of circular intensity differential scattering (CIDS),[6] showing that the angular differential scattering of left- and right-circularly polarized light can provide information about the geometry and handedness of helical structures.[7] In 1982, Tinoco and collaborators experimentally demonstrated angular CIDS from the helical sperm head of the octopus Eledone cirrhosa, observing preferential scattering of one circular polarization with a maximum differential signal of about 2% at a scattering angle of 35°.[8]
He is known for his pioneering work on RNA folding and the secondary structures of ribonucleic acid.[9][10][11] His graduate and postdoctoral students include Carlos Bustamante and Frances Arnold.[9]
His honors and awards include: Guggenheim Fellow, Medical Research Council Laboratory, Cambridge (1964); California Section Award, American Chemical Society (1965); D.Sc. University of New Mexico (1972); Member, National Academy of Sciences (1985); Elisabeth R. Cole Award (Founders Award), Biophysical Society (1996);[12] Berkeley Citation, University of California (1996); Member, American Academy of Arts and Sciences (2001); Emily M. Gray Award, Biophysical Society (2006); Fellow: American Physical Society, Biophysical Society.
He died on November 15, 2016, at the age of 85.[2]
The Biophysical Society gives the Ignacio Tinoco Award in his honor.[13]
References
[edit]- ↑ "Ignacio Tinoco Jr". John Simon Guggenheim Memorial Foundation. Retrieved November 26, 2018.
- 1 2 Wang, Linda (2016). "Ignacio Tinoco dies at age 85". Chemical & Engineering News. Retrieved November 26, 2018.
- ↑ "Emeriti Faculty". University of California, Berkeley. Archived from the original on June 20, 2012. Retrieved February 20, 2013.
- 1 2 Tinoco, I. (2002). "Physical Chemistry of Nucleic Acids". Annual Review of Physical Chemistry. 53: 1–15. Bibcode:2002ARPC...53....1T. doi:10.1146/annurev.physchem.53.082001.144341. PMID 11972000.
- ↑ "Ignacio Tinoco | College of Chemistry". chemistry.berkeley.edu. Archived from the original on March 14, 2018. Retrieved March 13, 2018.
- ↑ Le Gratiet, Aymeric; Marongiu, Riccardo; Diaspro, Alberto (2020). "Circular Intensity Differential Scattering for Label-Free Chromatin Characterization: A Review for Optical Microscopy". Polymers. 12 (10): 2428. doi:10.3390/polym12102428. PMC 7588990. PMID 33096877.
- ↑ Bustamante, Carlos; Maestre, Marcos F.; Tinoco, Ignacio Jr. (1980). "Circular intensity differential scattering of light by helical structures. I. Theory". The Journal of Chemical Physics. 73 (9): 4273–4281. Bibcode:1980JChPh..73.4273B. doi:10.1063/1.440709. OSTI 1133673.
- ↑ Maestre, Marcos F.; Bustamante, Carlos; Hayes, Thomas L.; Subirana, Juan A.; Tinoco, Ignacio Jr. (1982). "Differential scattering of circularly polarized light by the helical sperm head from the octopus Eledone cirrhosa". Nature. 298 (5876): 773–774. Bibcode:1982Natur.298..773M. doi:10.1038/298773a0. PMID 7110315.
- 1 2 Grens, Kerry (December 20, 2016). "Ignacio Tinoco, Luminary of RNA Folding, Dies". The Scientist. Retrieved November 26, 2018.
- ↑ TINOCO, IGNACIO; UHLENBECK, OLKE C.; LEVINE, MARK D. (April 9, 1971). "Estimation of Secondary Structure in Ribonucleic Acids". Nature. 230 (5293): 362–367. Bibcode:1971Natur.230..362T. doi:10.1038/230362a0. PMID 4927725. S2CID 4283534.
- ↑ TINOCO, IGNACIO; BORER, PHILIP N.; DENGLER, BARBARA; LEVINE, MARK D.; UHLENBECK, OLKE C.; CROTHERS, DONALD M.; GRALLA, JAY (November 1973). "Improved Estimation of Secondary Structure in Ribonucleic Acids". Nature New Biology. 246 (150): 40–41. doi:10.1038/newbio246040a0. PMID 4519026. Retrieved November 26, 2018.
- ↑ Founders Award page
- ↑ "Harry Noller to Receive 2019 BPS Ignacio Tinoco Award". BPS Newsroom. Biophysical Society. Retrieved November 26, 2018.
Further reading
[edit]- Tinoco, Ignacio (May 6, 2014). "Fun and Games in Berkeley: The Early Years (1956–2013)". Annual Review of Biophysics. 43 (1): 1–17. doi:10.1146/annurev-biophys-051013-022708. PMID 24702008.—Autobiographical article by Tinoco
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