Interferon lambda receptor 1
| IFNLR1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | IFNLR1, CRF2/12, IFNLR, IL-28R1, IL28RA, LICR2, Interleukin 28 receptor, alpha subunit, interferon lambda receptor 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 607404; MGI: 2429859; HomoloGene: 52086; GeneCards: IFNLR1; OMA:IFNLR1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Interferon lambda receptor 1 is a subunit for the interferon lambda receptor encoded by the IFNLR1 gene. It was formerly known as interleukin 28 receptor, alpha subunit. IL28RA is its human gene.
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukin 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with interferon type III (IL28A, IL28B, IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.[5]
References
[edit]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000185436 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062157 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: IL28RA interleukin 28 receptor, alpha (interferon, lambda receptor)".
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