Hippocalcin-like protein 4

HPCAL4
Identifiers
Aliases	HPCAL4, HLP4, hippocalcin like 4
External IDs	MGI: 2157521; GeneCards: HPCAL4
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.2 Start 39,678,648 bp End 39,691,485 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.2 Start 123,077,020 bp End 123,088,494 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe prefrontal cortex cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum anterior cingulate cortex dorsolateral prefrontal cortex nucleus accumbens amygdala Brodmann area 9 Top expressed in subiculum amygdala piriform cortex anterior amygdaloid area Region I of hippocampus proper nucleus accumbens prefrontal cortex primary motor cortex hippocampus proper dentate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding calcium channel regulator activity protein binding metal ion binding protein C-terminus binding protein domain specific binding Cellular component intracellular anatomical structure Biological process central nervous system development signal transduction Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 51440 170638 Ensembl ENSG00000116983 ENSMUSG00000046093 UniProt Q9UM19 Q8BGZ1 RefSeq (mRNA) NM_016257 NM_001282396 NM_001282397 NM_174998 RefSeq (protein) NP_001269325 NP_001269326 NP_057341 NP_778163 Location (UCSC) Chr 1: 39.68 – 39.69 Mb Chr 4: 123.08 – 123.09 Mb PubMed search
Wikidata
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Hippocalcin like 4, also known as HPCAL4, is a human gene.

Function

The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It also has similarity to rat neural visinin-like Ca2+-binding protein-type 1 and 2 proteins. It is a member of the neuronal calcium sensor family. This encoded protein may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The transcript of this gene has multiple polyadenylation sites.

Further reading

• Kobayashi M, Sakai E, Furuta Y, Takamatsu K (1999). "Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes". DNA Sequence. 9 (3): 171–6. doi:10.3109/10425179809072192. PMID 10520747.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.