Guanylate cyclase activator 2B

GUCA2B
Identifiers
Aliases	GUCA2B, GCAP-II, UGN, guanylate cyclase activator 2B
External IDs	OMIM: 601271; MGI: 1270851; HomoloGene: 5150; GeneCards: GUCA2B; OMA:GUCA2B - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UYA, 1UYB
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.2 Start 42,153,410 bp End 42,155,820 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D2.1|4 55.48 cM Start 119,513,804 bp End 119,516,151 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum mucosa of transverse colon mucosa of sigmoid colon jejunal mucosa duodenum rectum testicle right lobe of liver body of stomach epithelium of colon Top expressed in right kidney crypt of lieberkuhn of small intestine duodenum ileum human kidney jejunum proximal tubule epithelium of small intestine intestinal villus migratory enteric neural crest cell More reference expression data BioGPS n/a
Gene ontology Molecular function guanylate cyclase activator activity calcium sensitive guanylate cyclase activator activity Cellular component photoreceptor outer segment extracellular exosome extracellular region Biological process cGMP biosynthetic process excretion body fluid secretion negative regulation of blood pressure positive regulation of guanylate cyclase activity digestion cGMP-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2981 14916 Ensembl ENSG00000044012 ENSMUSG00000032978 UniProt Q16661 O09051 RefSeq (mRNA) NM_007102 NM_008191 RefSeq (protein) NP_009033 NP_032217 Location (UCSC) Chr 1: 42.15 – 42.16 Mb Chr 4: 119.51 – 119.52 Mb PubMed search
Wikidata
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Guanylate cyclase activator 2B is a protein that in humans is encoded by the GUCA2B gene.

Function

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys.

Further reading

• Sindić A, Hirsch JR, Velic A, Piechota H, Schlatter E (2005). "Guanylin and uroguanylin regulate electrolyte transport in isolated human cortical collecting ducts". Kidney Int. 67 (4): 1420–7. doi:10.1111/j.1523-1755.2005.00219.x. PMID 15780094.
• Guo HF, Gao PJ, Li Y, Zhu DL, Wang JG (2007). "[Association between uroguanylin G-247A polymorphism and blood pressure/fluid and electrolytes homeostasis]". Zhonghua Xin Xue Guan Bing Za Zhi (in Chinese). 35 (3): 233–6. PMID 17582287.
• Yoshikawa Y, Nakayama T, Saito K, Hui P, Morita A, Sato N, Takahashi T, Tamura M, Sato I, Aoi N, Doba N, Hinohara S, Soma M, Usami R (2007). "Haplotype-based case-control study of the association between the guanylate cyclase activator 2B (GUCA2B, Uroguanylin) gene and essential hypertension". Hypertens. Res. 30 (9): 789–96. doi:10.1291/hypres.30.789. PMID 18037771.
• Yoshikawa Y, Nakayama T, Saito K, Hui P, Morita A, Sato N, Takahashi T, Tamura M, Sato I, Aoi N, Doba N, Hinohara S, Soma M, Usami R (2007). "Haplotype-based case-control study of the association between the guanylate cyclase activator 2B (GUCA2B, Uroguanylin) gene and essential hypertension". Hypertens. Res. 30 (9): 789–96. doi:10.1291/hypres.30.789. PMID 18037771.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.