// Workers AI · dad joke modeWhy did the fringe gene go to therapy? It was feeling a little "edgy".
| Fringe | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FNG | ||||||
| InterPro | IPR017374 | ||||||
| Membranome | 1299 | ||||||
| |||||||
Fringe genes are important in the workings of the notch signaling pathway.[1]
In Drosophila melanogaster (the fruit fly) the fringe gene (fng) was identified as part of the notch mechanism by Dr. Kenneth Irvine at the Waksman Institute at Rutgers.[citation needed] Later based on similarity, the manic fringe (MFNG), the radical fringe (RFNG) and lunatic fringe (LFNG)[2][3] genes were identified in mammals.
Fringe genes encode O-fucose specific β-1,3-N-Acetylglucosaminyltransferases (GlcNAcT) glycosyltransferases.
The gene products of radical fringe stimulate the Apical Ectodermal Ridge in limb-bud formation.
The mouse and human Fringe family members map to three different chromosomes:
References
[edit]- ↑ Gazave E, Lapébie P, Richards GS, Brunet F, Ereskovsky AV, Degnan BM, et al. (October 2009). "Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes". BMC Evolutionary Biology. 9 (1): 249. Bibcode:2009BMCEE...9..249G. doi:10.1186/1471-2148-9-249. PMC 2770060. PMID 19825158.
- ↑ Hopkin M (6 November 2006). "Troublesome gene names get the boot". Nature. doi:10.1038/news061106-2. S2CID 86514270.
- ↑ White M (26 September 2014). "Sonic Hedgehog, Dicer, and the Problem With Naming Genes". Pacific Standard. The Social Justice Foundation.
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