Extended synaptotagmin-2

ESYT2
Identifiers
Aliases	ESYT2, CHR2SYT, E-Syt2, FAM62B, extended synaptotagmin protein 2, extended synaptotagmin 2
External IDs	OMIM: 616691; MGI: 1261845; HomoloGene: 32699; GeneCards: ESYT2; OMA:ESYT2 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DMG, 4NPJ, 4NPK, 4P42
Gene location (Human) Chr. Chromosome 7 (human) Band 7q36.3 Start 158,730,995 bp End 158,830,253 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12 F2|12 62.65 cM Start 116,244,816 bp End 116,354,670 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial membrane Achilles tendon saphenous vein synovial joint endothelial cell urethra cardiac muscle tissue of right atrium myocardium of left ventricle skin of arm skin of hip Top expressed in interventricular septum decidua uterus umbilical cord ascending aorta superior cervical ganglion secondary oocyte cervix granulocyte gastrula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium-dependent phospholipid binding calcium ion binding protein binding metal ion binding phosphatidylinositol binding phosphatidylethanolamine binding phosphatidylcholine binding identical protein binding lipid binding cadherin binding Cellular component intrinsic component of endoplasmic reticulum membrane organelle membrane contact site integral component of membrane extrinsic component of cytoplasmic side of plasma membrane plasma membrane integral component of plasma membrane membrane endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-plasma membrane contact site Biological process lipid transport endocytosis glycosphingolipid metabolic process transport endoplasmic reticulum-plasma membrane tethering Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57488 52635 Ensembl ENSG00000117868 ENSMUSG00000021171 UniProt A0FGR8 Q3TZZ7 RefSeq (mRNA) NM_020728 NM_028731 RefSeq (protein) NP_065779 NP_001354702 NP_083007 Location (UCSC) Chr 7: 158.73 – 158.83 Mb Chr 12: 116.24 – 116.35 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Extended synaptotagmin-2 is a protein that in humans is encoded by the ESYT2 gene.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
• Craxton M (2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.