// Workers AI · dad joke modeWhat did OTULIN say to its friend? "You're a cut above.

OTULIN
Identifiers
Aliases	OTULIN, FAM105B, GUM, OTU deubiquitinase with linear linkage specificity, AIPDS
External IDs	OMIM: 615712; MGI: 3577015; HomoloGene: 106591; GeneCards: OTULIN; OMA:OTULIN - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ZNV, 3ZNX, 3ZNZ, 4KSJ, 4KSK, 4KSL, 4OYK, 4P0B
Enzyme activity
Gene location (Human)
Chr.	Chromosome 5 (human)
End	14,699,850 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	27,630,779 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; bone marrow cell; ; pancreatic ductal cell; ; sural nerve; ; skin of arm; ; monocyte; ; Achilles tendon; ; tonsil; ; skin of abdomen; ; skin of leg;
	Top expressed in
	yolk sac; ; otic vesicle; ; left lobe of liver; ; right kidney; ; saccule; ; spermatid; ; granulocyte; ; soleus muscle; ; proximal tubule; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	cysteine-type peptidase activity; thiol-dependent deubiquitinase; peptidase activity; protein binding; hydrolase activity;
Cellular component	cytosol; LUBAC complex; cytoplasm;
Biological process	immune system process; Wnt signaling pathway; proteolysis; nucleotide-binding oligomerization domain containing 2 signaling pathway; angiogenesis; canonical Wnt signaling pathway; sprouting angiogenesis; protein linear deubiquitination; regulation of tumor necrosis factor-mediated signaling pathway; negative regulation of NF-kappaB transcription factor activity; innate immune response; negative regulation of inflammatory response; regulation of canonical Wnt signaling pathway; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	90268
	432940
	ENSG00000154124
	ENSMUSG00000046034
	Q96BN8
	Q3UCV8
	NM_138348
	NM_001013792
	NP_612357
	NP_001013814
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin thioesterase otulin is a protein in humans that is encoded by the OTULIN gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000154124 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046034 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Family with sequence similarity 105, member B". Retrieved 2012-11-19.

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// Workers AI · dad joke modeWhat did OTULIN say to its friend? "You're a cut above.

References

Further reading