Endonuclease, poly(U) specific

"ENDOU" redirects here. For the surname, see Endō.

ENDOU
Identifiers
Aliases	ENDOU, P11, PP11, PRSS26, endonuclease, poly(U) specific
External IDs	OMIM: 606720; MGI: 97746; HomoloGene: 48394; GeneCards: ENDOU; OMA:ENDOU - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.11 Start 47,709,734 bp End 47,725,567 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium oral cavity epithelium of esophagus mucosa of pharynx human penis body of tongue skin of abdomen vulva skin of arm skin of leg Top expressed in thymus esophagus lip skin of abdomen skin of external ear condyle skin of back hair follicle medial dorsal nucleus umbilical cord More reference expression data BioGPS n/a
Gene ontology Molecular function manganese ion binding polysaccharide binding metal ion binding scavenger receptor activity RNA binding nuclease activity endonuclease activity serine-type peptidase activity growth factor activity hydrolase activity endoribonuclease activity Cellular component cytoplasm plasma membrane extracellular region extracellular space Biological process nucleic acid phosphodiester bond hydrolysis female pregnancy receptor-mediated endocytosis proteolysis immune response RNA phosphodiester bond hydrolysis, endonucleolytic regulation of signaling receptor activity vesicle-mediated transport endocytosis signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8909 19011 Ensembl ENSG00000111405 ENSMUSG00000022468 UniProt P21128 n/a RefSeq (mRNA) NM_006025 NM_001172439 NM_001172440 NM_001168693 NM_008902 RefSeq (protein) NP_001165910 NP_001165911 NP_006016 n/a Location (UCSC) Chr 12: 47.71 – 47.73 Mb n/a PubMed search
Wikidata
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Endonuclease, poly(U) specific is a protein that in humans is encoded by the ENDOU gene.

Function

This gene encodes a protein with endoribonuclease activity and is expressed in the placenta. The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants have been found for this protein. [provided by RefSeq, Feb 2010].

References

Malard F, Dias K, Baudy M, Thore S, Vialet B, Barthélémy P, Fribourg F, Karginov FV, Campagne S (April 2025). "Molecular basis for the calcium-dependent activation of the ribonuclease EndoU". Nat. Commun. 16: 3110. doi:10.1038/s41467-025-58462-6. PMC 11961692.

Further reading

• Laneve P, Gioia U, Ragno R, Altieri F, Di Franco C, Santini T, Arceci M, Bozzoni I, Caffarelli E (December 2008). "The tumor marker human placental protein 11 is an endoribonuclease". J. Biol. Chem. 283 (50): 34712–9. doi:10.1074/jbc.M805759200. PMC 3259861. PMID 18936097.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.