Dynein regulatory complex protein 8

DRC8
Identifiers
Aliases	DRC8, CFAP200, EF-hand calcium binding domain 2, EFCAB2, Dynein Regulatory Complex Subunit 8
External IDs	MGI: 1915476; GeneCards: DRC8
Gene location (Human)
Chr.	Chromosome 1 (human)
End	245,127,164 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	178,312,078 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; Achilles tendon; ; sural nerve; ; C1 segment; ; bronchial epithelial cell; ; left lobe of thyroid gland; ; right testis; ; right lobe of thyroid gland; ; left testis; ; olfactory zone of nasal mucosa;
	Top expressed in
	seminiferous tubule; ; right ventricle; ; spermatid; ; myocardium of ventricle; ; lumbar subsegment of spinal cord; ; spermatocyte; ; choroidal fissure; ; interventricular septum; ; cardiac muscles; ; temporal muscle;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	84288
	68226
	ENSG00000203666
	ENSMUSG00000026495
	Q5VUJ9
	Q9CQ46
	NM_001143943; NM_001290327; NM_032328
	NM_026626
	NP_001137415; NP_001277256; NP_115704
	NP_080902
	Wikidata
View/Edit Human	View/Edit Mouse

Dynein regulatory complex protein 8 is a protein that in humans is encoded by the gene DRC8 (previously EFCAB2).^[5] This protein is predicted to be a component of the nexin-dynein regulatory complex (N-DRC) which regulates the movement of the cilium/flagellum.^[6]

Function

The gene encodes a protein that contains two EF-hand calcium-binding domains although its function has yet to be determined. Alternatively spliced transcripts have been observed.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000203666 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026495 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: EF-hand calcium binding domain 2". Retrieved 2017-06-01.
↑ "Dynein regulatory complex protein 8". uniprot.org. UniProt consortium. Retrieved 2026-09-24.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000203666 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026495 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EF-hand calcium binding domain 2". Retrieved 2017-06-01.

[6] "Dynein regulatory complex protein 8". uniprot.org. UniProt consortium. Retrieved 2026-09-24.

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Dynein regulatory complex protein 8

Function

References