DNA alpha-glucosyltransferase
| DNA alpha-glucosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.26 | ||||||||
| CAS no. | 9030-13-1 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In enzymology, a DNA alpha-glucosyltransferase (EC 2.4.1.26) is an enzyme that catalyzes the chemical reaction in which an alpha-D-glucosyl residue is transferred from UDP-glucose to a hydroxymethylcytosine residue in DNA.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:DNA alpha-D-glucosyltransferase. Other names in common use include uridine diphosphoglucose-deoxyribonucleate, alpha-glucosyltransferase, UDP-glucose-DNA alpha-glucosyltransferase, uridine diphosphoglucose-deoxyribonucleate, alpha-glucosyltransferase, T2-HMC-alpha-glucosyl transferase, T4-HMC-alpha-glucosyl transferase, and T6-HMC-alpha-glucosyl transferase.
Structural studies
[edit]As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1XV5, PDB: 1Y6F, PDB: 1Y6G, PDB: 1Y8Z, and PDB: 1YA6.
References
[edit]- Kornberg SR, Zimmerman SB, Kornberg A (1961). "Glucosylation of deoxyribonucleic acid by enzymes from bacteriophage-infected Escherichia coli". J. Biol. Chem. 236 (5): 1487–1493. doi:10.1016/S0021-9258(18)64202-4. PMID 13753193.
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