// Workers AI · dad joke modeWhat did Deoxycytidylate 5-hydroxymethyltransferase say? "I'm bonded to my work".
(Redirected from EC 2.1.2.8)
| Deoxycytidylate 5-hydroxymethyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.2.8 | ||||||||
| CAS no. | 9012-68-4 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Deoxycytidylate 5-hydroxymethyltransferase (EC 2.1.2.8) is an enzyme that catalyzes the chemical reaction
This tetrahydrofolate–dependent enzyme catalyzes a reversible substitution of the hydroxymethyl group from the cofactor 10-formyltetrahydrofolate (5,10-CH2-THF) to deoxycytidine dihydrogen phosphate, giving 5-hydroxymethyldeoxycytidylic acid and tetrahydrofolic acid (THF). The enzyme was characterised from Escherichia coli.[1]
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase. Other names in common use include dCMP hydroxymethylase, d-cytidine 5'-monophosphate hydroxymethylase, deoxyCMP hydroxymethylase, deoxycytidylate hydroxymethylase, and deoxycytidylic hydroxymethylase. This enzyme participates in pyrimidine metabolism.[2]
Structural studies
[edit]As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1B49, PDB: 1B5D, and PDB: 1B5E.
References
[edit]- ↑ Mathews CK, Brown F, Cohen SS (1964). "Virus-induced acquisition of metabolic function. VII. Biosynthesis de novo of deoxycytidylate hydroxymethylase". J. Biol. Chem. 239 (9): 2957–2963. doi:10.1016/S0021-9258(18)93838-X. PMID 14217882.
- ↑ Enzyme 2.1.2.8 at KEGG Pathway Database.
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