Dynein axonemal light chain 1
(Redirected from DNAL1)
| DNAL1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | DNAL1, C14orf168, CILD16, dynein axonemal light chain 1, LC1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 610062; MGI: 1921462; HomoloGene: 34623; GeneCards: DNAL1; OMA:DNAL1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Dynein axonemal light chain 1, (LC1) is a protein that in humans is encoded by the DNAL1 gene.[5][6]
Function
[edit]LC1 is a component of outer dynein arms, which contain the molecular motors for ATP-dependent cilia movement.[5][6]
Clinical significance
[edit]Mutations in the DNAL1 gene are associated with primary ciliary dyskinesia.[7]
References
[edit]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000119661 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042523 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- 1 2 "Entrez Gene: dynein".
- 1 2 Horváth J, Fliegauf M, Olbrich H, Kispert A, King SM, Mitchison H, Zariwala MA, Knowles MR, Sudbrak R, Fekete G, Neesen J, Reinhardt R, Omran H (July 2005). "Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients". Am. J. Respir. Cell Mol. Biol. 33 (1): 41–7. doi:10.1165/rcmb.2004-0335OC. PMID 15845866. S2CID 19776274.
- ↑ Lancaster MA, Gleeson JG (June 2009). "The primary cilium as a cellular signaling center: lessons from disease". Curr. Opin. Genet. Dev. 19 (3): 220–9. doi:10.1016/j.gde.2009.04.008. PMC 2953615. PMID 19477114.
External links
[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by adding missing information. |