DHAP (chemotherapy)
(Redirected from DHAP-R)
 | This article relies on a single source. (May 2021) |
| DHAP | |
|---|---|
| Specialty | Oncology |
DHAP in context of chemotherapy is an acronym for chemotherapy regimen that is used for remission induction in cases of relapsed or refractory non-Hodgkin lymphoma and Hodgkin lymphoma.[1] It is usually given for 2-3 courses, then followed by high-dose chemotherapy and autologous stem cell transplantation. In combination with anti-CD20 monoclonal antibody rituximab (Rituxan, Mabthera) it is called R-DHAP or DHAP-R.
[R]-DHAP regimen consists of:
- Rituximab, a monoclonal antibody, directed at B-cell surface antigen CD20
- Dexamethasone, a glucocorticoid hormone
- High-dose Ara-C - cytarabine, an antimetabolite;
- Platinol (cisplatin), a platinum-based antineoplastic, also an alkylating antineoplastic agent.
Dosing regimen
[edit]| Drug | Dose | Mode | Days |
|---|---|---|---|
| Rituximab | 375 mg/m2 | IV infusion | Day 0 |
| Dexamethasone | 40 mg | PO qd | Days 1-4 |
| High-dose Ara-C - cytarabine | 2000 mg/m2 | IV infusion over 2 hrs | Day 2, every 12 hours |
| Platinol (cisplatin) | 100 mg/m2 | IV infusion over 24 hrs | Day 1 |