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Hematopoietic cell signal transducer is a protein that in humans is encoded by the HCSTgene.[5][6]
This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptorNKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.[6]
Diefenbach A, Tomasello E, Lucas M, etal. (2002). "Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D". Nat. Immunol. 3 (12): 1142–9. doi:10.1038/ni858. PMID12426565. S2CID14901451.
Chang C, Dietrich J, Harpur AG, etal. (1999). "Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties". J. Immunol. 163 (9): 4651–4. doi:10.4049/jimmunol.163.9.4651. PMID10528161.
