// Workers AI · dad joke modeWhat did Daf-9 say to Daf-10? You're one digit ahead.
(Redirected from DAF-9)
| Cytochrome P450 daf-9 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | daf-9 | ||||||
| Alt. symbols | CYP22A1 | ||||||
| Entrez | 180889 | ||||||
| RefSeq (mRNA) | NM_001029732.2 | ||||||
| RefSeq (Prot) | NP_001024903.1 | ||||||
| UniProt | H2KYS3 | ||||||
| Other data | |||||||
| Chromosome | X: 6.2 - 6.2 Mb | ||||||
| |||||||
The daf-9 gene encodes a cytochrome p450 enzyme that catalyses the generation of dafachronic acid (a steroid hormone) in the worm Caenorhabditis elegans,[1][2] with the CYP Symbol CYP22A1 (Cytochrome P450, family 22, member A1). After generation, dafachronic acid will bind its nuclear receptor Daf-12, whose genetic mutation has been implicated by Cynthia Kenyon and colleagues as related to the formation of Dauer larva.[3]
References
[edit]- ↑ Jia K, Albert PS, Riddle DL (2002). "DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity". Development. 129 (1): 221–31. doi:10.1242/dev.129.1.221. PMID 11782415.
- ↑ Motola DL, Cummins CL, Rottiers V, Sharma KK, Li T, Li Y, Suino-Powell K, Xu HE, Auchus RJ, Antebi A, Mangelsdorf DJ (2006). "Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans". Cell. 124 (6): 1209–1223. doi:10.1016/j.cell.2006.01.037. PMID 16529801.
- ↑ Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993). "A C. elegans mutant that lives twice as long as wild type". Nature. 366 (6454): 461–464. Bibcode:1993Natur.366..461K. doi:10.1038/366461a0. PMID 8247153. S2CID 4332206.